Neurodevelopment and efferocytosis have fascinated scientists for decades. How an organism builds a nervous system that is precisely tuned for efficient behaviors and survival and how it simultaneously manages constant somatic cell turnover are complex questions that have resulted in distinct fields of study. Although neurodevelopment requires the overproduction of cells that are subsequently pruned back, very few studies marry these fields to elucidate the cellular and molecular mechanisms that drive nervous system development through the lens of cell clearance. In this review, we discuss these fields to highlight exciting areas of future synergy. We first review neurodevelopment from the perspective of overproduction and subsequent refinement and then discuss who clears this developmental debris and the mechanisms that control these events. We then end with how a more deliberate merger ofneurodevelopment and efferocytosis could reframe our understanding of homeostasis and disease and discuss areas of future study.

中文翻译：

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理清思绪：神经发育过程中细胞死亡后碎片清除的机制

几十年来，神经发育和胞吞作用一直让科学家们着迷。生物体如何构建精确调整以实现有效行为和生存的神经系统，以及如何同时管理持续的体细胞更新，这些都是复杂的问题，导致了不同的研究领域。尽管神经发育需要细胞的过量产生，随后又被修剪掉，但很少有研究将这些领域结合起来，以阐明通过细胞清除的角度驱动神经系统发育的细胞和分子机制。在这篇评论中，我们讨论这些领域，以突出未来协同作用的令人兴奋的领域。我们首先从过度生产和随后的细化的角度回顾神经发育，然后讨论谁清除这些发育碎片以及控制这些事件的机制。然后，我们以神经发育和胞吞作用的更慎重的合并如何重新构建我们对体内平衡和疾病的理解并讨论未来的研究领域作为结束。