Abstract

The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 ± 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N-methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.

摘要

研究了百里醌对大鼠在 6.0 ± 0.5 V/m 强度的 900 MHz 电磁场辐射下 15 天每天 1 小时的学习记忆能力和海马氧化应激的保护作用。辐射暴露大鼠的百里醌治疗（10 mg/kg/天）比未接受百里醌的辐射暴露大鼠产生更好的表现。电磁场暴露导致海马超氧化物歧化酶、谷胱甘肽过氧化物酶和丙二醛水平升高，脑源性神经营养因子水平降低；百里醌治疗改善了所有四个参数。此外，在电磁场暴露组中，N-甲基-D-天冬氨酸受体表达降低，γ-氨基丁酸α受体表达增加，这被百里醌治疗逆转。总之，用百里醌治疗改善了暴露于 EMF 的影响，并为涉及氧化应激的机制提供了线索。