ABSTRACT

Objective

The aim of this research was to explore the role and potential mechanism of long non-coding RNA PAXIP-AS1 in preeclampsia.

Methods

To investigate the effects of PAXIP-AS1 on cell viability, migration, and invasion. The miR-210-3p-targeted relationship with lncRNA PAXIP-AS1 or BDNF was verified.

Results

PAXIP-AS1 was inversely correlated with miR-210-3p and BDNF was targeted by miR-210-3p. BDNF was positively correlated with PAXIP-AS1 in the serum of preeclampsia patients. The promotion effects of PAXIP-AS1 on cell viability, migration, and invasion were reversed by miR-210-3p up-regulation or BDNF knockdown in trophoblast cells.

Conclusion

PAXIP-AS1 promoted the viability, migration, and invasion of trophoblast cells by regulating the miR-210-3p/BDNF axis.

中文翻译：

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长链非编码 RNA PAXIP-AS1 通过 miR-210-3p/BDNF 轴促进 HTR-8/SVneo 细胞的活力、侵袭和迁移

摘要

客观的

本研究旨在探讨长链非编码RNA PAXIP-AS1在先兆子痫中的作用和潜在机制。

方法

研究 PAXIP-AS1 对细胞活力、迁移和侵袭的影响。验证了 miR-210-3p 与 lncRNA PAXIP-AS1 或 BDNF 的靶向关系。

结果

PAXIP-AS1 与 miR-210-3p 呈负相关，BDNF 被 miR-210-3p 靶向。BDNF与先兆子痫患者血清中的PAXIP-AS1呈正相关。PAXIP-AS1 对细胞活力、迁移和侵袭的促进作用被滋养层细胞中 miR-210-3p 上调或 BDNF 敲低逆转。

结论

PAXIP-AS1 通过调节 miR-210-3p/BDNF 轴促进滋养层细胞的活力、迁移和侵袭。