Abstract

Pheromones could promote hormone secretions and regulate sexual behavior. It was unclear whether multiparous pheromone could induce variations in puberty. The aim was to ascertain whether pheromone in urine of multiparous females induced central precocious puberty (CPP) in juvenile C57BL/6J females. The precocious puberty was examined by vaginal smear, lordosis reaction, HE stain, and ELISA analysis. Results suggested that the first vaginal opening and the first estrus were significantly earlier. The time interval of the first vaginal opening and estrus was significantly shortened. It was interesting that the first estrus was significantly correlated with the first vaginal opening and the time interval of the first estrus. In the first estrus, female lordosis reaction, the number of mature follicles, and the weight of the ovary and uterus significantly increased. The level of luteinizing hormones also significantly increased. Thus, multiparous pheromone can regulate sex hormone to induce CPP in juvenile C57BL/6J females.

摘要

信息素可以促进激素分泌，调节性行为。目前尚不清楚经产信息素是否会引起青春期的变化。目的是确定经产女性尿液中的信息素是否会导致 C57BL/6J 女性中枢性性早熟 (CPP)。通过阴道涂片、前凸反应、HE染色和ELISA分析检查性早熟。结果表明，第一次阴道开口和第一次发情明显提前。第一次阴道口和发情的时间间隔明显缩短。有趣的是，第一次发情与第一次阴道开口和第一次发情的时间间隔显着相关。在第一次发情，女性前凸反应，成熟卵泡的数量，并且卵巢和子宫的重量显着增加。促黄体激素水平也显着增加。因此，经产信息素可以调节性激素诱导幼年 C57BL/6J 雌性 CPP。