Increased androgen level, hyperinsulinemia, diabetes, impaired fibrinolysis, obesity, hypertension, chronic inflammation, abnormal immune response to infections and hyperhomocysteinemia are the most common abnormalities related to polycystic ovary syndrome (PCOS) women and are the factors predisposing to the severe course of COVID-19. The SARS-Cov-2 infection during pregnancy is associated with an increased risk of complications (spontaneous abortion), similar to those in PCOS. The treatment of PCOS pregnant women with a history of fertility failures raises many doubts, especially during the COVID pandemic. However, due to the increasing incidence of infections among reproductive people and the potentially more serious course in pregnant women, numerous questions about the safety and effectiveness of the treatment are still very current. In our study we presented a series of cases of recurrent miscarriages or recurrent implantation failure PCOS pregnant women with confirmed COVID-19. The diagnosis of infertility confirmed the presence of plasminogen activator inhibitor type 1 and/or 5,10-methylenetetrahydrofolate reductase polymorphisms in each of them. Moreover, some of the women presented immune dysfunction associated with infertility. We have described the personalized treatments of each pregnant patient included: metformin, enoxaparin and tacrolimus. The treatment applied had the expected effect, supporting the implantation processes. Furthermore, despite the ambiguous data according to immunological therapy of infertile women during the COVID pandemic, we observed a mild or asymptomatic COVID-19 course and we noticed no pregnancy complications.

雄激素水平升高、高胰岛素血症、糖尿病、纤维蛋白溶解受损、肥胖、高血压、慢性炎症、对感染的异常免疫反应和高同型半胱氨酸血症是与多囊卵巢综合征 (PCOS) 女性相关的最常见异常，也是导致 COVID 严重病程的因素-19。怀孕期间感染 SARS-Cov-2 会增加并发症（自然流产）的风险，类似于 PCOS。有生育失败史的 PCOS 孕妇的治疗引起了许多疑问，尤其是在 COVID 大流行期间。然而，由于生殖人群中感染发生率的增加以及孕妇可能更严重的病程，有关治疗安全性和有效性的许多问题仍然非常普遍。在我们的研究中，我们介绍了一系列确诊为 COVID-19 的 PCOS 孕妇反复流产或反复植入失败的病例。不孕症的诊断证实了纤溶酶原激活物抑制剂 1 型和/或 5,10-亚甲基四氢叶酸还原酶多态性的存在。此外，一些女性表现出与不孕症相关的免疫功能障碍。我们已经描述了每位怀孕患者的个性化治疗，包括：二甲双胍、依诺肝素和他克莫司。所应用的治疗具有预期的效果，支持植入过程。此外，尽管 COVID 大流行期间不孕妇女免疫治疗的数据不明确，但我们观察到轻度或无症状的 COVID-19 病程，并且没有发现妊娠并发症。