Purpose: To describe two patients with intraocular lens (IOL) and lens capsule spread of iridociliary melanoma. Methods: Two pseudophakic patients with iridociliary body melanoma that spread onto the surface of their IOL and remaining lens capsule were included. Their eyes were enucleated and the histopathologic features were evaluated. Results: Case 1 was an 82-year-old woman with diffuse primary iridociliary melanoma affecting the iris, lens capsule, IOL surface, and ciliary body. Case 2 was a 68-year-old female who developed melanoma recurrence in the anterior segment after plaque brachytherapy for iridociliary melanoma. The melanoma in both cases grew as a pigmented membrane onto the surface of the IOL. Conclusions: Intraocular lens and lens capsule spread of iridociliary melanoma can occur primarily or develop secondarily after plaque brachytherapy of a pseudophakic eye. Since the extent of the melanoma may be uncertain and there is a high likelihood of glaucoma, enucleation is a reasonable option.


中文翻译：

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虹膜睫状体黑色素瘤人工晶状体及晶状体囊扩散2例临床及组织病理学特点

目的：描述两名患有人工晶状体（IOL）和晶状体囊扩散的虹膜睫状体黑色素瘤患者。方法：纳入了两名患有虹膜睫状体黑色素瘤的假晶状体患者，这些患者扩散到其 IOL 和剩余的晶状体囊表面。他们的眼睛被摘除并评估了组织病理学特征。结果：病例 1 是一名 82 岁的女性，患有影响虹膜、晶状体囊、IOL 表面和睫状体的弥漫性原发性虹膜睫状体黑色素瘤。病例 2 是一位 68 岁的女性，在虹膜睫状体黑色素瘤斑块近距离放疗后眼前节出现黑色素瘤复发。在这两种情况下，黑色素瘤都以色素膜的形式生长在 IOL 的表面上。结论：虹膜睫状体黑色素瘤的人工晶状体和晶状体囊扩散可在假晶状体眼的斑块近距离放射治疗后原发或继发发生。由于黑色素瘤的范围可能不确定并且青光眼的可能性很高，因此摘除术是一个合理的选择。