The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is closely associated with immune infiltration. However, the expression and prognosis of TRPV family and tumor-infiltrating immune cells in ccRCC are obscure. This study aimed to explore the prognostic and therapeutic value of the TRPV family expression in ccRCC from the perspective of bioinformatics. We analyzed the transcriptome and clinical data of kidney renal clear cell carcinoma (KIRC) from The Cancer Genome Atlas (TCGA) database. A clustering analysis and immune infiltration analysis were conducted to investigate the influence of the TRPV family genes on ccRCC. Our study found that the TRPV family is an excellent prognostic stratification for ccRCC. Among them, TRPV3 is the most significant prognostic marker of ccRCC. In addition, we performed a drug sensitivity analysis to identify the drugs with the strongest association with TRPV3. As a result, the TRPV family, particularly TRPV3, can act as a prognostic biomarker in ccRCC to determine prognosis and levels of immune infiltration.

中文翻译：

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TRPV家族对肾透明细胞癌预后和免疫浸润的综合分析。

已初步发现瞬时受体电位香草醛（TRPV）家族在各种癌症中发挥重要作用，包括与免疫浸润密切相关的透明细胞肾细胞癌（ccRCC）。然而，TRPV家族和肿瘤浸润免疫细胞在ccRCC中的表达和预后尚不清楚。本研究旨在从生物信息学的角度探讨TRPV家族表达在ccRCC中的预后和治疗价值。我们分析了癌症基因组图谱（TCGA）数据库中肾透明细胞癌（KIRC）的转录组和临床数据。进行聚类分析和免疫浸润分析以研究TRPV家族基因对ccRCC的影响。我们的研究发现，TRPV 家族是 ccRCC 的极好预后分层。其中，TRPV3是ccRCC最重要的预后标志物。此外，我们进行了药物敏感性分析，以确定与 TRPV3 关联最强的药物。因此，TRPV 家族，尤其是 TRPV3，可以作为 ccRCC 的预后生物标志物来确定预后和免疫浸润水平。