Any experiment conducted in a rodent laboratory is done so against the backdrop of each animal's physiological state at the time of the experiment. This physiological state can be the product of multiple factors, both internal (e.g., animal sex, strain, hormone cycles, or circadian rhythms) and external (e.g., housing conditions, social status, and light/dark phases). Each of these factors has the potential to influence experimental outcomes, either independently or via interactions with others, and yet there is little consistency across laboratories in terms of the weight with which they are considered in experimental design. Such discrepancies—both in practice and in reporting—likely contribute to the perception of a reproducibility crisis in the field of behavioral neuroscience. In this review, we discuss how several of these sources of variability can impact outcomes within the realm of common learning and memory paradigms.

中文翻译：

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在啮齿动物行为的实验室研究中考虑生物生理学

在啮齿动物实验室中进行的任何实验都是在实验时每只动物的生理状态的背景下进行的。这种生理状态可以是多种因素的产物，包括内部因素（例如，动物性别、应变、激素周期或昼夜节律）和外部因素（例如，居住条件、社会地位和光/暗阶段）。这些因素中的每一个都有可能独立地或通过与其他因素的相互作用影响实验结果，但在实验设计中考虑这些因素的权重方面，各个实验室之间几乎没有一致性。这种差异——无论是在实践中还是在报告中——可能会导致人们对行为神经科学领域的可重复性危机的看法。在这篇综述中，我们讨论了这些变异性来源如何影响常见学习和记忆范式领域的结果。