Introduction: To analyze the results of intraocular surgery in treated retinoblastoma eyes and to assess the long-term results with a priority on local recurrences, secondary enucleation and metastases. Methods: Retrospective noncomparative case series. Results: From March 1964 to January 2020, 43 eyes of 40 retinoblastoma patients underwent intraocular surgery. Time interval between last therapy and surgery was 9.5 years on average. Thirty eyes were treated for radiogenic cataract formation with a gain in visual acuity in 63.3%. One child developed an upper eyelid metastasis, 3 showed second primary malignancies (SPM), one a late recurrence and 2 eyes were enucleated. Retinal surgery was performed in 16 eyes, 6 eyes were done as a combined procedure. Indications were radiogenic complications in 10 eyes and a rhegmatogenous retinal detachment in 6 eyes. 43.75% had a postoperative gain in visual acuity. Two patients developed late recurrences, one a SPM and 4 eyes could not be preserved. Conclusion: Surgical therapy in treated retinoblastoma is necessary in isolated cases. In our series cataract surgery was a safe procedure with a good option of a significant increase in visual acuity. Vitreoretinal treated eyes showed a limited gain in visual acuity, a higher risk of late recurrences and a lower globe retention rate. Therefore preoperative high-quality imaging and individual risk-benefit analysis is mandatory.


中文翻译：

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视网膜母细胞瘤眼内眼手术后的长期结果

简介：分析经治疗的视网膜母细胞瘤眼内眼手术的结果，并评估长期结果，优先考虑局部复发、继发性眼球摘除和转移。方法：回顾性非比较病例系列。结果：1964年3月至2020年1月，40例视网膜母细胞瘤患者43只眼接受了眼内手术。最后一次治疗和手术之间的时间间隔平均为 9.5 年。30 只眼睛接受了放射源性白内障形成治疗，视力提高了 63.3%。一名儿童出现上眼睑转移，3 名患儿出现第二原发性恶性肿瘤 (SPM)，一名晚期复发，2 只眼被摘除眼球。视网膜手术16眼，联合手术6眼。适应症为放射源性并发症 10 只眼和孔源性视网膜脱离 6 只眼。43.75% 的患者术后视力有所提高。2例晚期复发，1例SPM，4只眼不能保全。结论：对于已治疗的视网膜母细胞瘤，手术治疗在个别病例中是必要的。在我们的系列中，白内障手术是一种安全的手术，可以显着提高视力。玻璃体视网膜治疗的眼睛显示视力增加有限，晚期复发风险较高，球体保留率较低。因此，术前高质量成像和个体风险收益分析是强制性的。在个别病例中，需要对已治疗的视网膜母细胞瘤进行手术治疗。在我们的系列中，白内障手术是一种安全的手术，可以显着提高视力。玻璃体视网膜治疗的眼睛显示视力增加有限，晚期复发风险较高，球体保留率较低。因此，术前高质量成像和个体风险收益分析是强制性的。在个别病例中，需要对已治疗的视网膜母细胞瘤进行手术治疗。在我们的系列中，白内障手术是一种安全的手术，可以显着提高视力。玻璃体视网膜治疗的眼睛显示视力增加有限，晚期复发风险较高，球体保留率较低。因此，术前高质量成像和个体风险收益分析是强制性的。