BACKGROUND Reactive gastropathy (RG) is an adaptive response to assaults of the gastric mucosa. Demographic information regarding RG as well as the coincidence of RG and gastrointestinal cancer are poorly characterized entities. OBJECTIVE Herein, we aim to investigate relationships of RG to both modifiable and nonmodifiable risk factors, as well as conduct a stratified analysis by race in an ethnically diverse, urban population. METHODS In this retrospective study, we queried an urban hospital inpatient pathology database searching for patients with surgical gastric biopsies positive for RG between March 25, 2015, and March 25, 2016. Of the 728 patients with a final diagnosis of RG, 292 were selected based on strict inclusion and exclusion criteria. We explored risk factors and conducted a stratified analysis for associations based on patient demographics. RESULTS In this urban minority population, nonsteroidal anti-inflammatory drugs (NSAIDs) were the most common medication associated with RG (Fig. 1), as well as the most common cause of RG, followed by chronic bile reflux. In addition, significant differences in demographics and gastropathic characteristics associated with RG, stratified by ethnicity, were found (Fig. 2). Notably, Hispanics, African Americans, and Caucasians had the highest rate of concomitant RG and diabetes, hypertension, and tobacco/alcohol use, respectively. CONCLUSION Our study indicated that NSAID usage is the most common cause of RG, followed by bile reflux-mediated mucosal injury, in an ethnically diverse urban US-based population. Of note, few patients had intestinal metaplasia, suggesting it to be a slow or negligent sequela of RG.

中文翻译：

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城市人口反应性胃病的病因分析。

背景反应性胃病(RG)是对胃黏膜侵袭的适应性反应。关于 RG 的人口统计信息以及 RG 和胃肠道癌的巧合是特征不佳的实体。目标在此，我们旨在调查 RG 与可改变和不可改变的风险因素之间的关系，并在不同种族的城市人口中按种族进行分层分析。方法 在这项回顾性研究中，我们查询了一个城市医院住院病理数据库，搜索了 2015 年 3 月 25 日至 2016 年 3 月 25 日期间手术胃活检为 RG 阳性的患者。在最终诊断为 RG 的 728 名患者中，选择了 292 名基于严格的纳入和排除标准。我们探索了风险因素，并根据患者人口统计数据对关联进行了分层分析。结果 在这个城市少数民族人群中，非甾体抗炎药 (NSAIDs) 是与 RG 相关的最常见药物（图 1），也是 RG 的最常见原因，其次是慢性胆汁反流。此外，发现与 RG 相关的人口统计学和胃病特征存在显着差异，按种族分层（图 2）。值得注意的是，西班牙裔、非裔美国人和高加索人的 RG 和糖尿病、高血压和烟草/酒精使用率分别最高。结论 我们的研究表明，在美国不同种族的城市人口中，使用 NSAID 是 RG 的最常见原因，其次是胆汁反流介导的黏膜损伤。值得注意的是，