Background Rheumatoid arthritis (RA) has unclear pathogenesis, but the molecules that feed its inflammatory state are known. Small interfering RNAs (siRNAs) are useful to identify molecular targets and evaluate the efficacy of specific drugs, and can themselves be used for therapeutic purposes. Sources of data A systematic search of different databases to March 2022 was performed to define the role of siRNAs in RA therapy. Twenty suitable studies were identified. Areas of agreement Small interfering RNAs can be useful in the study of inflammatory processes in RA, and identify possible therapeutic targets and drug therapies. Areas of controversy Many genes and cytokines participate in the inflammatory process of RA and can be regulated with siRNA. However, it is difficult to determine whether the responses to siRNAs and other drugs studied in human cells in vitro are similar to the responses in vivo. Growing points Inflammatory processes can be affected by the gene dysregulation of siRNAs on inflammatory cytokines. Areas timely for developing research To date, it is not possible to determine whether the pharmacological response of siRNAs on cells in vitro would be similar to what takes place in vivo for the diseases studied so far.

中文翻译：

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小干扰 RNA 在人类类风湿性关节炎治疗中的作用

背景类风湿性关节炎 (RA) 的发病机制尚不清楚，但导致其炎症状态的分子是已知的。小干扰 RNA (siRNA) 可用于识别分子靶点和评估特定药物的功效，并且本身可用于治疗目的。数据来源 对截至 2022 年 3 月的不同数据库进行了系统搜索，以确定 siRNA 在 RA 治疗中的作用。确定了 20 项合适的研究。协议领域 小干扰 RNA 可用于研究 RA 的炎症过程，并确定可能的治疗靶点和药物疗法。争议领域 许多基因和细胞因子参与 RA 的炎症过程，并且可以通过 siRNA 进行调节。然而，很难确定在体外对人体细胞中研究的 siRNA 和其他药物的反应是否与体内反应相似。生长点 炎症过程可能受到炎症细胞因子上 siRNA 基因失调的影响。适合开展研究的领域 迄今为止，尚无法确定 siRNA 在体外对细胞的药理反应是否与迄今为止研究的疾病在体内发生的反应相似。