ABSTRACT

Congenital heart defects have been associated with adverse neurodevelopmental outcomes due to factors that result in a hypoxic-ischemic cerebral cumulative effect. We present a pair of fraternal twins: the first twin was healthy, and the second was born with a complex congenital heart defect (CCHD). They were followed for growth and neurodevelopmental outcomes to determine the comparative effect of exposure to a CCHD. Results show that exposure to a CCHD could be related to a persistent motor deficiency with hypotonia and concurrent height for age delay. CCHD requires a comprehensive neurodevelopmental approach; the pathophysiology and the surrounding stimuli are influential.

摘要

由于导致缺氧缺血性脑累积效应的因素，先天性心脏缺陷与不良的神经发育结果相关。我们介绍了一对异卵双胞胎：第一个双胞胎很健康，第二个出生时患有复杂的先天性心脏缺陷 (CCHD)。他们对生长和神经发育结果进行了跟踪，以确定暴露于 CCHD 的比较效果。结果表明，暴露于 CCHD 可能与持续性运动缺陷伴肌张力减退和年龄延迟并发身高有关。CCHD 需要全面的神经发育方法；病理生理学和周围的刺激是有影响的。