This paper presents antimalarial activity of several triphenyltin(IV) aminobenzoate compounds synthesized from the reaction of triphenyltin(IV) hydroxide with 2-, 3-, and 4-aminobenzoic acid. The activity of the compounds as anti-malaria agents was evaluated using Plasmodium falciparum, and demonstrated that the compounds have about the same IC50 with that of chloroquine (2×10−3 μg/mL) applied as the positive control. The result also showed that the Plasmodium is non-resistent to the compounds synthesized, which is the opposite to chloroquine.

中文翻译：

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三苯基锡（IV）氨基苯甲酸酯类化合物的合成及抗疟活性

本文介绍了由氢氧化三苯基锡 (IV) 与 2-、3- 和 4-氨基苯甲酸反应合成的几种氨基苯甲酸三苯基锡 (IV) 化合物的抗疟活性。化合物作为抗疟疾剂的活性使用以下方法评估恶性疟原虫，并证明这些化合物具有大致相同的 IC50与氯喹（2×10-3μg/mL) 作为阳性对照。结果还表明，疟原虫对合成的化合物不耐药，与氯喹相反。