ABSTRACT

In a clever experimental design, Tallman, Clark, and Smith (this issue) tested the changes in fMRI activation and functional connectivity in the hippocampus and cortex as a function of memory age. They found that activation changed according to a power function (both increasing and decreasing) in several cortical regions but not within the hippocampus or medial temporal lobe (MTL). Further, functional connectivity increased with memory age between cortical regions but decreased for the hippocampus. Taken together, these results offer strong support for the standard consolidation model. However, they leave open the question of what role the hippocampus plays in recognition memory performance.

摘要

在巧妙的实验设计中，Tallman、Clark 和 Smith（本期）测试了海马体和皮层中 fMRI 激活和功能连接的变化随记忆年龄的变化。他们发现，在几个皮层区域中，激活根据幂函数（增加和减少）而变化，但在海马体或内侧颞叶 (MTL) 中没有变化。此外，功能连接随着皮质区域之间的记忆年龄增加而增加，但海马体减少。总而言之，这些结果为标准合并模型提供了强有力的支持。然而，他们没有解决海马体在识别记忆表现中扮演什么角色的问题。