Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights into the contribution of lncRNAs to AML development and revealed connections between lncRNA expression and clinical parameters in AML patients. In this mini review, we illustrate the versatile functions of lncRNAs in AML, with a focus on pediatric AML, and present examples that may serve as future therapeutic targets or predictive factors.

中文翻译：

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长链非编码 RNA 作为小儿急性髓细胞白血病的调节因子

长链非编码 RNA (lncRNA) 越来越多地成为人类发育和疾病的调节因子，其中许多已在造血和白血病发生的背景下进行了描述。这些研究对 lncRNA 对 AML 发展的贡献产生了新的分子见解，并揭示了 lncRNA 表达与 AML 患者临床参数之间的联系。在这篇小型综述中，我们说明了 lncRNA 在 AML 中的多种功能，重点关注儿科 AML，并提供了可能作为未来治疗靶点或预测因素的例子。