Background. In Parkinson’s disease (PD), verb-naming tasks have been proposed as superior to noun-naming ones in detecting language deficits, although such an hypothesis is not supported at a statistical level. Objectives. Providing diagnostic accuracy evidence for a verb- and noun-naming task in detecting cognitive impairment in PD patients. Method. Thirty-three consecutive PD patients were subdivided into participants with (PD-CI; N=12) or without cognitive impairment (CI) (cognitively unimpaired, PD-CU; N=21), based on a raw score ≤25 or >25 on the Mini-Mental State Examination (MMSE), respectively. The Noun- and Verb-Naming Task (NNT, VNT) by Crepaldi et al. (2006) was administered. Diagnostic accuracy on the NNT and VNT was assessed through receiver-operating characteristics (ROC) analyses by comparing PD-CU to PD-CI patients. At the optimal cut-off, sensitivity, specificity, positive and negative predictive values (PPV, NPV) and likelihood ratios (LR+, LR-) were separately tested for the NNT and VNT against PD-CU vs. PD-CI classification. Results. Diagnostic accuracy was higher for the NNT (AUC =.85; p=.001) vs. the VNT (AUC =.68; p=.092). Consistently, the NNT yielded higher sensitivity, specificity and post-test features than the VNT (NNT: sensitivity =.75; specificity=.81; PPV =.69; NPV =.85; LR+ =3.94; LR- =.31; VNT: sensitivity=.67; specificity =.67; PPV =.53; NPV =.78; LR+ =2; LR- =.5). Conclusions. In accordance with the Movement Disorders Society guidelines, noun-naming tasks are diagnostically sound psychometric instruments to discriminate PD patients with vs. without CI. However, these findings need replication by (1) employing a gold standard different from the MMSE, which does not capture the full range of cognitive impairment in this population and (2) sub-dividing PD patients into those with mild cognitive impairment and dementia.


中文翻译：

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名词和动词命名任务在检测帕金森病认知障碍中的诊断准确性

背景。在帕金森病 (PD) 中，已提出动词命名任务在检测语言缺陷方面优于名词命名任务，尽管在统计水平上不支持这样的假设。目标。为检测 PD 患者认知障碍的动词和名词命名任务提供诊断准确性证据。方法。根据原始评分≤25 或 >25，将 33 名连续 PD 患者细分为有（PD-CI；N=12）或无认知障碍（CI）（认知未受损，PD-CU；N=21）的参与者分别在简易精神状态检查（MMSE）上。Crepaldi 等人的名词和动词命名任务（NNT，VNT）。（2006）被管理。通过比较 PD-CU 和 PD-CI 患者，通过接受者操作特征 (ROC) 分析评估 NNT 和 VNT 的诊断准确性。在最佳截止值时，针对 PD-CU 与 PD-CI 分类分别测试 NNT 和 VNT 的敏感性、特异性、阳性和阴性预测值（PPV、NPV）和似然比（LR+、LR-）。结果。NNT (AUC =.85; p=.001) 与 VNT (AUC =.68; p=.092) 相比，诊断准确性更高。一致地，NNT 产生了比 VNT 更高的敏感性、特异性和测试后特征（NNT：敏感性 =.75；特异性=.81；PPV =.69；NPV =.85；LR+ =3.94；LR- =.31； VNT：敏感性 =.67；特异性 =.67；PPV =.53；NPV =.78；LR+ =2；LR- =.5)。结论。根据运动障碍协会指南，名词命名任务是诊断上合理的心理测量工具，用于区分患有与不患有 CI 的 PD 患者。然而，