Universities play a unique role in ecosystems of innovation. They interact with the other agents of the Triple Helix model, developing their functions in relation to each other and together with industry and government. Grounded in key conceptual frameworks—Triple Helix, Regional Innovation Systems and Entrepreneurial University—we analyze how the leading universities in Silicon Valley (UC Berkeley, Stanford and UC San Francisco) have evolved, adapting to new demands and, in turn, shaping the evolution of Silicon Valley. To do so we use quantitative and qualitative data and examine the changes occurring between 2007 and 2018. A close examination of the data from this period reveals an increased attention to entrepreneurship education and an intensified activity of technology transfer offices. Equally relevant are the increased interactions between universities and investors (business angels, Venture Capital funds and corporate investors), and the improvement of specific infrastructures to incubate and accelerate business ideas.

大学在创新生态系统中发挥着独特的作用。它们与三螺旋模型的其他主体相互作用，发展它们相互之间以及与行业和政府相关的功能。基于关键的概念框架——三螺旋、区域创新系统和创业大学——我们分析了硅谷领先的大学（加州大学伯克利分校、斯坦福大学和加州大学旧金山分校）如何发展、适应新需求并反过来塑造发展硅谷的。为此，我们使用定量和定性数据，并研究 2007 年至 2018 年之间发生的变化。仔细研究这一时期的数据表明，人们对创业教育的关注度越来越高，技术转让办公室的活动也越来越多。