ABSTRACT

Where memories are stored in the brain is an age-old question in psychology and neuroscience alike. In particular, whether hippocampus-encoded memories are transferred to the cortex or remain hippocampus-dependent over time has not been definitely answered. New evidence from fMRI studies in humans suggest that while hippocampo-cortical connections lose weight during declarative memory consolidation, the hippocampus – alongside corticocortical connections – stays equally engaged between recent and remote memory recall. These findings lend experimental support for the indexing theory of memory consolidation, which postulates the hippocampus to act as a librarian to retrieve the cortical books of memory.

摘要

记忆存储在大脑中的什么地方是心理学和神经科学领域的一个古老问题。特别是，海马体编码的记忆是转移到皮层还是随着时间的推移保持海马体依赖性尚未明确回答。来自人类 fMRI 研究的新证据表明，虽然海马体-皮质连接在陈述性记忆巩固过程中会减轻重量，但海马体——连同皮质皮质连接——在近期和远期记忆回忆之间保持同等的参与度。这些发现为记忆巩固的索引理论提供了实验支持，该理论假定海马体充当图书管理员来检索皮质记忆书籍。