ABSTRACT

This study aims to investigate the effects of pre- and postnatal 2450 MHz continuous wave (CW) radiofrequency radiation (RFR) on the thymus of rats spanning four generations. Four groups; sham, irradiated female, irradiated male, irradiated male and female, each consisting of four rats (one male and three females), were created. During the experiment, rats in the exposure groups were whole-body exposed to 2450 MHz CW-RFR for 12 h/day. Irradiation started one month before the fertilization in the experimental group. When the offspring were two months old, four rats, one male and three female, were allocated for the second-generation study. The remaining offspring were sacrificed under general anesthesia, and their thymuses were removed. The same procedure was applied to the next generation. Two months after the second generation gave birth, third-generation rats were decapitated, and their thymuses were removed. In all groups, cortex, medulla and resident cells could be clearly distinguished in the second and third generations. No differences were observed between the control and two experimental groups, defined as irradiated female and irradiated male. In contrast, vascularization was observed in the thymus of the fourth-generation offspring of the group where both males and females were irradiated. The number of offspring and mass of all rats decreased in the third-generation group. Pre-and postnatal 2450 MHz continuous wave radiofrequency radiation exposure may potentially affect the thymus of future generations.

摘要

本研究旨在研究产前和产后 2450 MHz 连续波 (CW) 射频辐射 (RFR) 对四代大鼠胸腺的影响。四组；sham、辐照雌性、辐照雄性、辐照雄性和雌性，每只由四只大鼠（一只雄性和三只雌性）组成。实验过程中，暴露组大鼠全身暴露于2450 MHz CW-RFR 12 h/d。实验组在受精前1个月开始照射。当后代两个月大时，分配了四只大鼠，一只雄性和三只雌性，用于第二代研究。在全身麻醉下处死剩余的后代，并取出它们的胸腺。同样的程序也适用于下一代。第二代生下两个月后，第三代大鼠被斩首，胸腺被摘除。在所有组中，皮层、髓质和常驻细胞在第二代和第三代都可以清楚地区分。在对照组和两个实验组之间没有观察到差异，定义为受辐射的女性和受辐射的男性。相比之下，在雄性和雌性都受到照射的组的第四代后代的胸腺中观察到血管化。第三代组所有大鼠的后代数量和质量均有所下降。产前和产后 2450 MHz 连续波射频辐射暴露可能会影响后代的胸腺。第二代和第三代可以清楚地区分髓质和常驻细胞。在对照组和两个实验组之间没有观察到差异，定义为受辐射的女性和受辐射的男性。相比之下，在雄性和雌性都受到照射的组的第四代后代的胸腺中观察到血管化。第三代组所有大鼠的后代数量和质量均有所下降。产前和产后 2450 MHz 连续波射频辐射暴露可能会影响后代的胸腺。第二代和第三代可以清楚地区分髓质和常驻细胞。在对照组和两个实验组之间没有观察到差异，定义为受辐射的女性和受辐射的男性。相比之下，在雄性和雌性都受到照射的组的第四代后代的胸腺中观察到血管化。第三代组所有大鼠的后代数量和质量均有所下降。产前和产后 2450 MHz 连续波射频辐射暴露可能会影响后代的胸腺。在雄性和雌性均受到照射的组的第四代后代的胸腺中观察到血管化。第三代组所有大鼠的后代数量和质量均有所下降。产前和产后 2450 MHz 连续波射频辐射暴露可能会影响后代的胸腺。在雄性和雌性均受到照射的组的第四代后代的胸腺中观察到血管化。第三代组所有大鼠的后代数量和质量均有所下降。产前和产后 2450 MHz 连续波射频辐射暴露可能会影响后代的胸腺。