This paper is devoted to the interfacial aspects of the intraocular behavior, migration and distribution of commonly injected ophthalmic drugs in eyes filled with medical-grade 1300 cSt silicone oil used as a retinal tamponade agent. Novel in vitro and ex vivo models were created for studying the physical properties of the retinal surface and interfacial spreading of the ophthalmic drugs over retinas. In vitro model experiments showed that the droplets of all tested drugs sank rapidly in the silicone oil to contact with the plasma-treated glass and then rapidly spread over the glass surface. In the ex vivo model, the migration phase was followed by contact with and rapid spread/absorption by the retinal interface. The wetting behavior of drugs under contact with the glass substrate and retinas was similar. The characteristic timescales of drug spreading, controlled by the viscous dissipation, were close. All tested drugs migrated to the retinal surface and rapidly spread across the retinal surface. This suggests that intravitreal drugs might be used effectively in eyes filled with silicone oil tamponade, as they rapidly migrate to and spread over the retinal surface.

中文翻译：

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玻璃体内注射药物在硅油填充眼模型中的界面行为

本文致力于眼内常用注射眼科药物的眼内行为、迁移和分布的界面方面，这些眼科药物填充有用作视网膜填塞剂的医用级 1300 cSt 硅油。创建了新的体外和离体模型，用于研究视网膜表面的物理特性和眼科药物在视网膜上的界面扩散。体外模型实验表明，所有测试药物的液滴在硅油中迅速下沉，与等离子体处理的玻璃接触，然后迅速扩散到玻璃表面。在离体模型中，迁移阶段之后是与视网膜界面接触并快速扩散/吸收。与玻璃基板和视网膜接触的药物的润湿行为是相似的。由粘性耗散控制的药物扩散的特征时间尺度很接近。所有测试的药物都迁移到视网膜表面并迅速扩散到整个视网膜表面。这表明玻璃体内药物可有效用于充满硅油填塞物的眼睛，因为它们会迅速迁移并扩散到视网膜表面。