Voltage-gated Ca2+ (Cav) channels play pivotal roles in regulating gene transcription, neuronal excitability, and neurotransmitter release. To meet the spatial and temporal demands of visual signaling, Cav channels exhibit unusual properties in the retina compared to their counterparts in other areas of the nervous system. In this article, we review current concepts regarding the specific subtypes of Cav channels expressed in the retina, their intrinsic properties and forms of modulation, and how their dysregulation could lead to retinal disease.

中文翻译：

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视网膜功能和疾病中的钙通道

电压门控钙2+（钙v）通道在调节基因转录、神经元兴奋性和神经递质释放方面发挥着关键作用。为了满足视觉信号的空间和时间需求，Cav与神经系统其他区域的对应通道相比，视网膜中的通道表现出不寻常的特性。在本文中，我们回顾了有关 Ca 特定亚型的当前概念v视网膜中表达的通道、其内在特性和调节形式，以及它们的失调如何导致视网膜疾病。