The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients.

中文翻译：

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COVID-19 在诱导 DNA 损伤中的潜在作用

由严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 引起的 2019 冠状病毒病 (COVID-19) 正在挑战全球卫生和经济系统。在某些人中，COVID-19 会引起多种症状，影响肺、心脏、肠道、肾脏和大脑等多个器官，导致多器官衰竭、败血症和死亡。这些影响部分与这些器官的直接病毒感染、免疫失调、高凝状态和细胞因子风暴综合征发展的可能性有关。由于 COVID-19 是最近出现的，因此对康复患者健康的长期影响仍然未知。在这篇综述中，我们重点关注冠状病毒介导的 DNA 损伤机制的当前证据。数据支持这些病毒可以引起 DNA 损伤、基因组不稳定、和细胞周期在它们在哺乳动物细胞中的复制过程中失调。由于 DNA 损伤的诱导和异常的 DNA 修复机制与癌症、糖尿病、神经退行性疾病和动脉粥样硬化等慢性疾病的发展有关，因此解决 COVID-19 康复患者的类似影响和结果非常重要。