Abstract Benzothiazole derivatives are essential intermediates in synthesizing a wide variety of medical and pharmaceutical compounds, and there is a great demand for a simple and efficient method to synthesize benzothiazoles under mild reaction conditions. Organic electrosynthesis as an energy-efficient process represents an environmentally benign and safer method than traditional methods for organic synthesis. Herein, we present bromine-free and straightforward synthesis of 2-amino benzothiazole derivatives via the reaction of aniline derivatives and ammonium thiocyanate using electrosynthesis in the presence of sodium bromide both as an electrolyte and as a brominating agent at room temperature in isopropyl alcohol (i-PrOH) as a solvent. The reaction of ammonium thiocyanate via C–H thiolation routes, using various aniline derivatives, resulted in a simple, green, and bromine-free synthesis of 2-amino benzothiazole in moderate to good yields under mild reaction conditions. Riluzole drug can be produced using the same procedure in moderate yields.

中文翻译：

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C-H硫醇化电合成苯并噻唑衍生物

摘要 苯并噻唑衍生物是合成多种医药化合物必不可少的中间体，迫切需要一种简单、高效、反应条件温和的苯并噻唑类化合物合成方法。有机电合成作为一种节能工艺，与传统的有机合成方法相比，是一种环境友好且更安全的方法。在此，我们提出了通过苯胺衍生物和硫氰酸铵的反应，在溴化钠作为电解质和溴化剂的存在下，在室温下在异丙醇中进行无溴且直接的合成 2-氨基苯并噻唑衍生物（i -PrOH) 作为溶剂。硫氰酸铵通过 C-H 硫醇化路线的反应，使用各种苯胺衍生物，在温和的反应条件下以中等至良好的收率合成了简单、绿色和无溴的 2-氨基苯并噻唑。利鲁唑药物可以使用相同的程序以中等产量生产。