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Para toluenesulfonic acid-catalyzed one-pot, three-component synthesis of benzo[5,6]chromeno[3,2-c]quinoline compounds in aqueous medium
Heterocyclic Communications ( IF 2.3 ) Pub Date : 2021-01-01 , DOI: 10.1515/hc-2020-0128
Naser Sadeghpour Orang 1 , Hadi Soltani 1 , Mehdi Ghiamirad 2 , Mehdi Ahmadi Sabegh 3
Affiliation  

Abstract A new series of benzo[5,6]chromeno[3,2-c]quinoline derivatives were successfully synthesized using various arylglyoxal monohydrates, quinoline-2,4-dione, and β-naphthol in H2O:EtOH (2:1) as a green solvent in the presence of catalytic amounts p-toluenesulfonic acid as a mild catalyst under reflux conditions with high yields (83–92%). The reaction conditions were optimized in different solvents at variable thermal conditions, and the optimized reaction condition for this synthesis has been reported. The structures of all new products were defined by 1H-NMR, 13C-NMR, FT-IR, mass spectral data, and HRMS.

中文翻译:

对甲苯磺酸催化一锅法、三组分在水介质中合成苯并[5,6]色烯并[3,2-c]喹啉化合物

摘要 使用各种芳基乙二醛一水合物、喹啉-2,4-二酮和β-萘酚在H2O:EtOH (2:1)中成功合成了一系列新的苯并[5,6]色烯[3,2-c]喹啉衍生物在催化量的对甲苯磺酸存在下作为绿色溶剂,在回流条件下作为温和催化剂,收率高(83-92%)。反应条件在不同的溶剂中在不同的热条件下进行了优化,并且已经报道了该合成的优化反应条件。所有新产品的结构均通过 1H-NMR、13C-NMR、FT-IR、质谱数据和 HRMS 确定。
更新日期:2021-01-01
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