Abstract The emergence of drug-resistant bacteria and the lack of effective antimicrobial agents have posed a threat to public safety, so a new efficient strategy is needed to deal with the increasing severity of bacteria. Herein, a substitute antibacterial agent with high stability and biocompatibility was synthesized by incorporating lysine hydrochloride and copper sulfate pentahydrate following the liquid-phase synthesis method. The composition and structure of the Cu(ii) complex (Lys–Cu) were characterized by performing ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffractometry (XRD), thermogravimetric analysis-differential scanning calorimetry, and single-crystal XRD. The crystal structure of Lys–Cu belongs to a monoclinic system, space group P21, with cell parameters of a = 5.14350(10), b = 16.8308(2), c = 11.4915(2) Å, Z = 2, and D = 1.548 g·cm−3. Bacteriostatic tests were carried out on Escherichia coli and Staphylococcus aureus. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of Lys–Cu against S. aureus were 0.3125 and 0.9250 mg·mL−1, respectively. The MIC and MBC values of Lys–Cu against bacterial strain E. coli were 0.4685 and 0.9250 mg·mL−1, respectively.

中文翻译：

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赖氨酸盐酸盐Cu(ii)配合物的制备和表征及其轰炸细菌耐药性的潜力

摘要 耐药菌的出现和有效抗菌药物的缺乏已经对公共安全构成威胁，因此需要一种新的有效策略来应对日益严重的细菌。在此，采用液相合成法，将赖氨酸盐酸盐和五水硫酸铜混合，合成了一种具有高稳定性和生物相容性的替代抗菌剂。采用紫外-可见分光光度法、傅里叶变换红外光谱法、X射线衍射法(XRD)、热重分析-差示扫描量热法和单晶法对Cu(ii)配合物(Lys-Cu)的组成和结构进行了表征XRD。Lys-Cu的晶体结构属于单斜晶系，空间群P21，晶胞参数a = 5.14350(10)，b = 16.8308(2), c = 11.4915(2) Å, Z = 2, D = 1.548 g·cm-3。对大肠杆菌和金黄色葡萄球菌进行了抑菌试验。Lys-Cu对金黄色葡萄球菌的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)分别为0.3125和0.9250 mg·mL-1。Lys-Cu对大肠杆菌的MIC和MBC值分别为0.4685和0.9250 mg·mL-1。