Quadruple collaboration has risen rapidly in place of the traditional triple helix model of institutional collaboration between universities, governments, and companies. Loet Leydesdorff and Helen Lawton Smith (2022) approach this challenge by aiming to resolve the issue of evaluating and analyzing various quadruple and n-tuple helices. This article seeks to recognize the increasing complexity of new and developing issues in quadruple and n-tuple helices as a response to their research. Higher order helices raise a number of important scientific difficulties, including conceptual and practical issues. The goal of this contribution is to highlight some of the major challenges involved with researching multiple helixes in terms of knowledge innovation, as well as to offer some alternative areas for future research on n-tuple helices measurement.

四方合作迅速兴起，取代了传统的大学、政府和公司之间机构合作的三螺旋模式。Loet Leydesdorff 和 Helen Lawton Smith (2022) 通过旨在解决评估和分析各种四重和 n 元组螺旋的问题来应对这一挑战。本文旨在认识到四重和 n 元组螺旋中新问题和发展中问题的日益复杂性，作为对他们研究的回应。高阶螺旋提出了许多重要的科学难题，包括概念和实践问题。这一贡献的目的是强调在知识创新方面研究多重螺旋所涉及的一些主要挑战，并为未来的 n 元组螺旋测量研究提供一些替代领域。