To date, various reports have exhibited the antidiabetic activity of plant extracts, but this activity could be improved through the conversion of plant bioactives into metal nanoparticles. Aqueous plant extracts were prepared from two plants, Zingiber officinale and Mentha longifolia. Silver nanoparticles from aqueous plant extracts were synthesized and characterized through spectroscopic techniques, including ultraviolet–visible spectroscopy and Fourier transform infrared spectroscopy and scanning electron microscopy, in comparison with their respective plant extracts. After successful synthesis, these nanoparticles were evaluated for biological potentials of antioxidant, antimicrobial and antidiabetic activities. The nanoparticles of both plants offered outstanding antidiabetic potential, but the silver nanoparticles of Z. officinale showed the highest inhibition potential of 80.52% to α-amylase even at lower concentrations. The synthesized nanoparticles were found to be better antimicrobial agents against Bacillus subtilis and Escherichia coli as measured through a well diffusion assay as compared with aqueous extracts. These nanoparticles offered antioxidant potential that was better than that of their plant extracts but was slightly lower than that of the positive control gallic acid. This study gives a direction for improvement of the biological activity of plant-based medicine through green synthesis of silver nanoparticles.

中文翻译：

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生姜和长叶薄荷的生物活性引导纳米颗粒合成

迄今为止，各种报道都展示了植物提取物的抗糖尿病活性，但这种活性可以通过将植物生物活性物质转化为金属纳米颗粒来提高。从两种植物姜和长叶薄荷制备水性植物提取物。通过光谱技术，包括紫外-可见光谱和傅里叶变换红外光谱和扫描电子显微镜，合成了来自水性植物提取物的银纳米颗粒，并与其各自的植物提取物进行了比较。成功合成后，评估了这些纳米颗粒的抗氧化、抗微生物和抗糖尿病活性的生物潜力。两种植物的纳米颗粒都具有出色的抗糖尿病潜力，但 Z. 即使在较低浓度下，officinale 对 α-淀粉酶的抑制潜力最高，为 80.52%。与水提取物相比，通过井扩散测定法测量，发现合成的纳米颗粒对枯草芽孢杆菌和大肠杆菌具有更好的抗菌作用。这些纳米颗粒提供的抗氧化能力优于其植物提取物，但略低于阳性对照没食子酸。本研究为通过银纳米粒子的绿色合成提高植物性药物的生物活性指明了方向。与水提取物相比，通过井扩散测定法测量，发现合成的纳米颗粒对枯草芽孢杆菌和大肠杆菌具有更好的抗菌作用。这些纳米颗粒提供的抗氧化能力优于其植物提取物，但略低于阳性对照没食子酸。本研究为通过银纳米粒子的绿色合成提高植物性药物的生物活性指明了方向。与水提取物相比，通过井扩散测定法测量，发现合成的纳米颗粒对枯草芽孢杆菌和大肠杆菌具有更好的抗菌作用。这些纳米颗粒提供的抗氧化能力优于其植物提取物，但略低于阳性对照没食子酸。本研究为通过银纳米粒子的绿色合成提高植物性药物的生物活性指明了方向。