Abstract

Context

Western diet and unhealthy lifestyle have contributed to the continued growth of type 2 diabetes mellitus (T2DM). T2DM is associated with dysbacteriosis, and studies have found that altering the gut microbiota has a positive effect on treatment.

Objective

In addition to hyperglycaemia, T2DM often causes damage to multiple organs. However, there are few studies on organ damage from faecal microbiota transplantation (FMT).

Materials and methods

T2DM mice were divided into four groups and were given phosphate buffered saline (PBS) (T2DM group), FMT (FMT group), Lactobacillus (LAB group), and Bifidobacterium (BIO group) by gavage for six weeks, respectively. Mice on a normal diet (control group) were gavaged with PBS for six weeks.

Results

After gavage treatment, FMT, LAB, and BIO groups were similar in lowering glucose, endotoxemia was slightly reduced, and the colonic mucus layer and liver lobules developed towards normal tissue. Surprisingly, we found that the FMT group had unique effects on islet cell regeneration, increased functional β cells, and insulin sensitivity.

Discussion and conclusion

Lactobacillus has the best glucose-lowering effect, but FMT has obvious advantages in β-cell regeneration, which provides new treatment ideas for tissue damage caused by T2DM.

中文翻译：

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粪便微生物群移植优于益生菌对小鼠 2 型糖尿病损伤的组织再生

摘要

语境

西方饮食和不健康的生活方式促成了 2 型糖尿病 (T2DM) 的持续增长。T2DM 与菌群失调有关，研究发现改变肠道菌群对治疗有积极作用。

客观的

除了高血糖外，T2DM 还经常对多个器官造成损害。然而，很少有关于粪便微生物群移植（FMT）对器官损伤的研究。

材料和方法

T2DM小鼠分为四组，分别灌胃磷酸盐缓冲液（PBS）（T2DM组）、FMT（FMT组）、乳酸杆菌（LAB组）和双歧杆菌（BIO组）6周。正常饮食的小鼠（对照组）用 PBS 灌胃六周。

结果

灌胃治疗后，FMT、LAB、BIO组降糖作用相似，内毒素血症略有减少，结肠粘液层和肝小叶向正常组织发展。令人惊讶的是，我们发现 FMT 组对胰岛细胞再生、增加功能性 β 细胞和胰岛素敏感性具有独特的作用。

讨论和结论

乳酸杆菌的降糖效果最好，而FMT在β细胞再生方面优势明显，为T2DM引起的组织损伤提供了新的治疗思路。