Background

Trichosporon asahii, an emerging fungal pathogen, has been frequently associated with invasive infections in critically ill patients.

Case report

A 74-year-old male patient diagnosed with COVID-19 was admitted to an Intensive Care Unit (ICU). During hospitalization, the patient displayed episodes of bacteremia by Staphylococcus haemolyticus and a possible urinary tract infection by T. asahii. While the bacterial infection was successfully treated using broad-spectrum antibiotics, the fungal infection in the urinary tract was unsuccessfully treated with anidulafungin and persisted until the patient died.

Conclusions

With the evolving COVID-19 pandemic, invasive fungal infections have been increasingly reported, mainly after taking immunosuppressant drugs associated with long-term broad-spectrum antibiotic therapy. Although Candida and Aspergillus are still the most prevalent invasive fungi, T. asahii and other agents have emerged in critically ill patients. Therefore, a proper surveillance and diagnosing any fungal infection are paramount, particularly in COVID-19 immunocompromised populations.

中文翻译：

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重症 COVID-19 患者可能发生朝日毛孢子菌尿路感染

背景

Trichosporon asahii是一种新兴的真菌病原体，经常与重症患者的侵袭性感染有关。

案例报告

一名被诊断为 COVID-19 的 74 岁男性患者被送入重症监护室 (ICU)。在住院期间，患者出现溶血性葡萄球菌菌血症发作和可能的朝日菌尿路感染。虽然使用广谱抗生素成功治疗了细菌感染，但用阿尼芬净治疗尿路真菌感染并没有成功，并一直持续到患者死亡。

结论

随着 COVID-19 大流行的不断发展，侵袭性真菌感染的报道越来越多，主要是在服用与长期广谱抗生素治疗相关的免疫抑制剂之后。虽然念珠菌和曲霉仍然是最普遍的侵袭性真菌，但朝日孢子菌和其他病原体已经出现在危重病人身上。因此，对任何真菌感染进行适当的监测和诊断至关重要，尤其是在 COVID-19 免疫功能低下的人群中。