Abstract

Dopamine concentration abnormalities in the body can cause various disorders and diseases such as Parkinson's, Tourette's syndrome, and depression. In this study, graphene oxide (GO) was combined with Fe₃O₄ to sensitively and selectively detect dopamine. The performance was evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The results of testing with CV on the solution [Fe(CN)₆] showed that a modification with GO gave a maximum effective surface area value of 0.0127 cm², proving that GO can increase the effective area and conductivity of the sensor. DPV testing shows that dopamine detection using GO/Fe₃O₄ has a linear range at a concentration of 1–10 μM with a detection limit of 0.48 μM and a quantification limit of 1.6 μM. GO/Fe₃O₄ also shows good selectivity where the peak current is separated by 0.245 V with ascorbic acid, which is the closest interference compound.

摘要

体内多巴胺浓度异常会导致各种失调和疾病，例如帕金森氏症、图雷特氏症候群和抑郁症。在这项研究中，氧化石墨烯 (GO) 与 Fe ₃ O ₄结合，可以灵敏、选择性地检测多巴胺。通过循环伏安法（CV）和差分脉冲伏安法（DPV）方法评估性能。对溶液[Fe(CN) ₆ ]进行CV测试的结果表明，GO改性后的最大有效表面积值为0.0127 cm ²，证明GO可以增加传感器的有效面积和电导率。DPV 测试表明使用 GO/Fe ₃ O _{4检测多巴胺}在浓度为 1-10 μM 时具有线性范围，检测限为 0.48 μM，定量限为 1.6 μM。GO/Fe ₃ O ₄也显示出良好的选择性，其中峰值电流与最接近的干扰化合物抗坏血酸相隔 0.245 V。