In this work, the rapid, facile, and eco-friendly green process was introduced in the preparation of β-cyclodextrin/magnetic iron oxide nanoparticles by using the aqueous Mentha longifolia extracts of Mentha longifolia. The obtained nanoparticles were characterised by Fourier transform infrared spectroscopy, x-ray powder diffraction, field emission scanning electron microscope, and thermogravimetric analysis. Also, effective factors on the synthesis of magnetic nanocomposites including temperature, concentration of the Mentha longifolia extract, and concentration of FeSO4 solution were optimised by Taguchi design. Moreover, important effective parameters on the adsorption efficiency; such as adsorbent dosage, pH, contact time, and temperature were investigated. The prepared magnetic nanocomposite was applied as a nanocarrier for imatinib mesylate delivery. In vitro studies confirmed imatinib mesylate release over 6 h. The nanocarrier showed pH-dependent imatinib mesylate release with higher drug release at simulated cancer fluid (pH = 5.6) compared to neural fluid (pH = 7.4). Moreover, the sorption isotherms and kinetics for the magnetic nanocomposite were fitted into Langmuir and pseudo-second order models, respectively. Based on the thermodynamic results, the adsorption of imatinib mesylate onto the nanoadsorbent was found to be spontaneous and exothermic.

中文翻译：

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使用长叶薄荷绿色生物合成磁性氧化铁纳米颗粒用于甲磺酸伊马替尼递送。

在这项工作中，利用长叶薄荷的水提取物，将快速、简便、环保的绿色工艺引入β-环糊精/磁性氧化铁纳米粒子的制备中。通过傅里叶变换红外光谱、X射线粉末衍射、场发射扫描电子显微镜和热重分析对得到的纳米颗粒进行了表征。此外，通过田口设计优化了磁性纳米复合材料合成的影响因素，包括温度、长叶薄荷提取物浓度和 FeSO4 溶液浓度。此外，吸附效率的重要有效参数；对吸附剂用量、pH、接触时间和温度等进行了研究。制备的磁性纳米复合材料用作甲磺酸伊马替尼递送的纳米载体。体外研究证实甲磺酸伊马替尼释放超过 6 小时。与神经液 (pH = 7.4) 相比，纳米载体显示出 pH 依赖性甲磺酸伊马替尼释放，在模拟癌液 (pH = 5.6) 中药物释放更高。此外，磁性纳米复合材料的吸附等温线和动力学分别符合 Langmuir 和准二级模型。基于热力学结果，发现甲磺酸伊马替尼在纳米吸附剂上的吸附是自发的和放热的。磁性纳米复合材料的吸附等温线和动力学分别拟合到 Langmuir 和准二级模型中。基于热力学结果，发现甲磺酸伊马替尼在纳米吸附剂上的吸附是自发的和放热的。磁性纳米复合材料的吸附等温线和动力学分别拟合到 Langmuir 和准二级模型中。基于热力学结果，发现甲磺酸伊马替尼在纳米吸附剂上的吸附是自发的和放热的。