Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis,ASN Neuro

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Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis
ASN Neuro ( IF 4.7 ) Pub Date : 2022-07-06 , DOI: 10.1177/17590914221112352
Jeffrey L Dupree _{1,

2} , Pablo M Paez ₃ , Seema K Tiwari-Woodruff ₄ , Travis T Denton _{5,

6,

7} , Kenneth Hensley ₈ , Christina G Angeliu ₃ , Anne I Boullerne ₉ , Sergey Kalinin ₉ , Sophia Egge ₁ , Veronica T Cheli ₃ , Giancarlo Denaroso ₃ , Kelley C Atkinson ₄ , Micah Feri ₄ , Douglas L Feinstein _{9,

10}

Affiliation

Department of Anatomy and Neurobiology, 6889Virginia Commonwealth University, Richmond, VA, USA.
Research Service, 20125HH McGuire VA Medical Center, Richmond, VA, USA.
Institute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, 12292University at Buffalo, NY, USA.
Division of Biomedical Sciences, 8790School of Medicine at the University of California Riverside, Riverside, CA, USA.
Department of Pharmaceutical Sciences, College of Pharmacy & Pharmaceutical Sciences, Washington State University Health Sciences Spokane, Spokane, WA, USA.
Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University Health Sciences Spokane, Spokane, WA, USA.
Steve Gleason Institute for Neuroscience, 445950Washington State University Health Sciences Spokane, Spokane, WA, USA.
477020Arkansas College of Osteopathic Medicine, Fort Smith, AR, USA.
Department Anesthesiology, University of Illinois, Chicago, IL, USA.
Jesse Brown VA Medical Center, Chicago, IL, USA.

Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showe...

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