Psychiatric polygenic risk scores (PRS) have potential utility in psychiatric care and prevention, but there are concerns about their implementation. We surveyed 960 US-based practicing child and adolescent psychiatrists' (CAP) about their experiences, perspectives, and potential uses of psychiatric PRS. While 23% of CAP reported that they had never heard of PRS, 10 % of respondents have had a patient/family bring PRS to them and 4% have generated PRS for patients. Though 25% stated they would request PRS if a patient/caregiver asked, 35% indicated that nothing would prompt them to request PRS. Most respondents (54%) believed psychiatric PRS are currently at least slightly useful and 87% believed they will be so in 5 years. More than 70% indicated they would take action in response to a child with a top fifth percentile psychiatric PRS but no diagnosis: 48% would increase monitoring of symptoms, 42% would evaluate for current symptoms, and 4% would prescribe medications. Yet, most respondents were concerned that high-PRS results could lead to overtreatment and negatively impact patients' emotional well-being. Findings indicate emerging use of psychiatric PRS within child and adolescent psychiatry in the US. It is critical to examine the ethical and clinical challenges that PRS may generate and begin efforts to promote their informed and responsible use.

中文翻译：

---

精神病多基因风险评分：儿童和青少年精神病学家的知识、态度和经验

精神病多基因风险评分（PRS）在精神病护理和预防方面具有潜在效用，但对其实施存在担忧。我们对 960 名美国执业儿童和青少年精神科医生 (CAP) 进行了调查，了解他们的经验、观点以及精神科 PRS 的潜在用途。虽然 23% 的 CAP 表示他们从未听说过 PRS，但 10% 的受访者让患者/家人将 PRS 带给他们，4% 的受访者为患者生成了 PRS。尽管 25% 的受访者表示，如果患者/护理人员提出要求，他们会申请 PRS，但 35% 的受访者表示，没有什么会促使他们申请 PRS。大多数受访者 (54%) 认为精神科 PRS 目前至少有一点用处，87% 的人认为 5 年后将会如此。超过 70% 的受访者表示，他们会针对患有前 5 个百分位精神 PRS 但未诊断的儿童采取行动：48% 的受访者会加强对症状的监测，42% 的受访者会评估当前症状，4% 的受访者会开药。然而，大多数受访者担心高 PRS 结果可能导致过度治疗并对患者的情绪健康产生负面影响。研究结果表明，美国儿童和青少年精神病学中越来越多地使用精神病学 PRS。至关重要的是要审查 PRS 可能产生的伦理和临床挑战，并开始努力促进其知情和负责任的使用。