During organismal development, organs and systems are built following a genetic blueprint that produces structures capable of performing specific physiological functions. Interestingly, we have learned that the physiological activities of developing tissues also contribute to their own morphogenesis. Specifically, physiological activities such as fluid secretion and cell contractility generate hydrostatic pressure that can act as a morphogenetic force. Here, we first review the role of hydrostatic pressure in tube formation during animal development and discuss mathematical models of lumen formation. We then illustrate specific roles of the notochord as a hydrostatic scaffold in anterior-posterior axis development in chordates. Finally, we cover some examples of how fluid flows influence morphogenetic processes in other developmental contexts. Understanding how fluid forces act during development will be key for uncovering the self-organizing principles that control morphogenesis.

中文翻译：

---

静水压在动物发育中的形态发生作用

在有机体发育过程中，器官和系统是按照遗传蓝图构建的，该蓝图产生能够执行特定生理功能的结构。有趣的是，我们了解到发育组织的生理活动也有助于其自身的形态发生。具体来说，液体分泌和细胞收缩性等生理活动会产生静水压力，可以充当形态发生力。在这里，我们首先回顾静水压力在动物发育过程中管形成中的作用，并讨论管腔形成的数学模型。然后，我们说明脊索作为静水力支架在脊索动物前后轴发育中的具体作用。最后，我们介绍了流体流动如何影响其他发育环境中形态发生过程的一些例子。了解流体力在发育过程中如何作用将是揭示控制形态发生的自组织原理的关键。