Background: 

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, standardized neuropsychological test that assesses several areas of cognitive function. Recent studies, although sparse, have examined the use of the RBANS to detect cognitive deficits in individuals with manifest Huntington disease (HD); however, no studies have investigated its utility to detect cognitive deficits in individuals with premanifest HD (PreHD), where cognitive symptoms are thought to be more subtle.

Objective: 

To assess cognitive deficits in individuals with HD, particularly in individuals with PreHD, using an easily administered, brief but comprehensive, neuropsychological test.

Method: 

We administered the RBANS to 31 individuals with HD, 29 individuals with PreHD, and 22 healthy controls (HC) at an academic HD clinical research center and collected RBANS Total, Index, and subtest scores for group comparisons.

Results: 

The HD group had significantly lower RBANS Total, Index, and subtest scores than the HC. The PreHD group had significantly lower RBANS Total scores and Coding subtest scores than the HC, but no other significant group differences were identified.

Conclusion: 

Our results substantiate previous findings of significant impairment on the RBANS in individuals with HD. In addition, we are the first to demonstrate that, although the RBANS can identify deficits in psychomotor speed and information processing in individuals with PreHD, it does not appear to have the ability to detect impairment in any additional cognitive domains in individuals with PreHD.

中文翻译：

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用于评估神经心理状态的可重复电池虽然可用于测量明显亨廷顿病的认知变化，但在明显疾病中的效用可能有限

背景： 

用于评估神经心理状态的可重复电池 (RBANS) 是一项简短的标准化神经心理学测试，可评估认知功能的多个领域。最近的研究虽然很少，但已经检验了使用 RBANS 来检测患有明显亨廷顿病 (HD) 的个体的认知缺陷；然而，尚无研究调查其在检测 HD 前期 (PreHD) 患者认知缺陷方面的效用，因为 HD 患者的认知症状被认为更为微妙。

客观的： 

使用易于管理、简短但全面的神经心理学测试来评估 HD 患者（尤其是 PreHD 患者）的认知缺陷。

方法： 

我们对 HD 学术临床研究中心的 31 名 HD 患者、29 名 PreHD 患者和 22 名健康对照 (HC) 进行了 RBANS，并收集了 RBANS 总分、指数和分项测试分数以进行组间比较。

结果： 

HD 组的 RBANS 总分、指数和分项测试分数均显着低于 HC 组。PreHD 组的 RBANS 总分和编码分项测试分数显着低于 HC 组，但没有发现其他显着的组间差异。

结论： 

我们的结果证实了之前关于 HD 患者 RBANS 显着受损的发现。此外，我们首次证明，尽管 RBANS 可以识别 PreHD 个体的精神运动速度和信息处理缺陷，但它似乎没有能力检测 PreHD 个体的任何其他认知领域的损伤。