Purpose of Review

Diabetes is an ongoing public health issue in the USA, and, despite progress, recent reports suggest acute and chronic diabetes complications are increasing.

Recent Findings

The Natural Experiments for Translation in Diabetes 3.0 (NEXT-D3) Network is a 5-year research collaboration involving six academic centers (Harvard University, Northwestern University, Oregon Health & Science University, Tulane University, University of California Los Angeles, and University of California San Francisco) and two funding agencies (Centers for Disease Control and Prevention and National Institutes of Health) to address the gaps leading to persisting diabetes burdens. The network builds on previously funded networks, expanding to include type 2 diabetes (T2D) prevention and an emphasis on health equity. NEXT-D3 researchers use rigorous natural experiment study designs to evaluate impacts of naturally occurring programs and policies, with a focus on diabetes-related outcomes.

Summary

NEXT-D3 projects address whether and to what extent federal or state legislative policies and health plan innovations affect T2D risk and diabetes treatment and outcomes in the USA; real-world effects of increased access to health insurance under the Affordable Care Act; and the effectiveness of interventions that reduce barriers to medication access (e.g., decreased or eliminated cost sharing for cardiometabolic medications and new medications such as SGLT-2 inhibitors for Medicaid patients). Overarching goals include (1) expanding generalizable knowledge about policies and programs to manage or prevent T2D and educate decision-makers and organizations and (2) generating evidence to guide the development of health equity goals to reduce disparities in T2D-related risk factors, treatment, and complications.

中文翻译：

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评估影响糖尿病流行的自然实验：NEXT-D3 网络简介

审查目的

糖尿病在美国是一个持续存在的公共卫生问题，尽管取得了进展，但最近的报告表明急性和慢性糖尿病并发症正在增加。

最近的发现

糖尿病翻译自然实验 3.0 (NEXT-D3) 网络是一个为期 5 年的研究合作项目，涉及六个学术中心（哈佛大学、西北大学、俄勒冈健康与科学大学、杜兰大学、加州大学洛杉矶分校和美国大学）加利福尼亚州旧金山）和两个资助机构（疾病控制与预防中心和美国国立卫生研究院）来解决导致持续存在的糖尿病负担的差距。该网络以之前资助的网络为基础，扩展到包括 2 型糖尿病 (T2D) 预防和对健康公平的重视。NEXT-D3 研究人员使用严格的自然实验研究设计来评估自然发生的计划和政策的影响，重点关注与糖尿病相关的结果。

概括

NEXT-D3 项目旨在解决美国联邦或州立法政策和健康计划创新是否以及在多大程度上影响 T2D 风险以及糖尿病治疗和结果；根据《平价医疗法案》增加获得医疗保险的机会对现实世界的影响；以及减少药物获取障碍的干预措施的有效性（例如，减少或消除心脏代谢药物和新药物（例如医疗补助患者的 SGLT-2 抑制剂）的费用分摊）。总体目标包括 (1) 扩大有关管理或预防 T2D 的政策和计划的普遍知识，并对决策者和组织进行教育；(2) 生成证据来指导健康公平目标的制定，以减少 T2D 相关风险因素、治疗方面的差异和并发症。