Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are major age-related concerns in elderly people. Since no drug fully addresses the progression of neurodegenerative diseases, advance treatment strategies are urgently needed. Several studies have noted the senescence of immune system and the perturbation of gut microbiota in the aged population. In recent years, the role of gut microbiota has been increasingly studied in the manifestation of age-related CNS disorders. In this context, prebiotics, probiotics, and paraprobiotics are reported to improve the behavioural and neurobiological abnormalities in elderly patients. As live microbiota, prescribed in the form of probiotics, shows some adverse effects like sepsis, translocation, and horizontal gene transfer, paraprobiotics could be a possible alternative strategy in designing microbiome-based therapeutics. This review describes the health-beneficial effects of paraprobiotics in age-associated neurodegenerative diseases.

神经退行性疾病，包括阿尔茨海默病和帕金森病，是老年人与年龄相关的主要问题。由于没有药物可以完全解决神经退行性疾病的进展，因此迫切需要先进的治疗策略。一些研究已经注意到免疫系统的衰老和老年人肠道微生物群的扰动。近年来，越来越多地研究肠道微生物群在与年龄相关的中枢神经系统疾病的表现中的作用。在此背景下，据报道益生元、益生菌和副益生菌可改善老年患者的行为和神经生物学异常。由于以益生菌形式开出的活微生物群显示出一些不良反应，如败血症、易位和水平基因转移，副益生菌可能是设计基于微生物组的疗法的一种可能的替代策略。这篇综述描述了副益生菌在与年龄相关的神经退行性疾病中的健康有益作用。