Introduction: The use of technetium 99m diethylenetriaminepentaacetic acid-galactosyl human serum albumin (^99mTc-GSA) scintigraphy parameters, HH15 and LHL15, in assessing the future liver remnant function is not expedient because of their nonlinear behaviour against liver volume. Uptake rate constant for the binding of ^99mTc-GSA to asialoglycoprotein receptors is probably more favourable, but the reported calculation methods are complex. We devised a simple method to calculate the uptake rate constant, KrGSA. Methods: Radioactivity counts for the entire liver and heart regions were extracted at 10, 20, and 30 min. Using whole liver and heart volumes measured from single-photon emission computed tomography images, free radioactivity corresponding to the liver blood pool was subtracted. The time activity curve was fitted to the equation L(t) = L(∞) × [1 − Exp (−kt)] using Microsoft Office Excel (add-in free programme Solver)®, where L(∞) is the count at plateau level and k denotes KrGSA. Results: KrGSA values accurately identified liver cirrhosis and were similar to the KICG. The areas under the curve for KrGSA and KICG in the receiver operating characteristic analysis were 0.808 and 0.795, respectively, and a good correlation was seen between KrGSA and KICG. Discussion/Conclusion: KrGSA can be utilized as an alternative to KICG in assessing the future liver remnant function.
Visc Med

中文翻译：

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99mTc-GSA 闪烁显像中肝脏摄取率常数对接受肝切除术患者风险分层的有用性：一种新的计算方法

简介：使用锝 99m 二亚乙基三胺五乙酸-半乳糖基人血清白蛋白 ( ^99m Tc-GSA) 闪烁显像参数 HH15 和 LHL15 评估未来的肝残余功能并不合适，因为它们对肝体积的非线性行为。^99m Tc-GSA 与去唾液酸糖蛋白受体结合的摄取速率常数可能更有利，但报道的计算方法很复杂。我们设计了一种计算摄取速率常数 K r GSA 的简单方法。方法：在 10、20 和 30 分钟时提取整个肝脏和心脏区域的放射性计数。使用从单光子发射计算机断层扫描图像测量的整个肝脏和心脏体积，减去对应于肝脏血池的游离放射性。使用 Microsoft Office Excel（附加免费程序 Solver）®将时间活动曲线拟合到方程L ( t ) = L (∞) × [1 − Exp (− kt )]，其中L (∞) 是计数在高原水平和k表示 K r GSA。结果： K r GSA 值准确识别肝硬化，与 KICG 相似。K r曲线下的面积受试者工作特征分析中的GSA和KICG分别为0.808和0.795，K r GSA与KICG之间具有良好的相关性。讨论/结论： K r GSA 可作为 KICG 的替代品用于评估未来的肝残余功能。
维斯克医学