Polycaprolactone (PCL) and silk fibroin are used to make nanofiber wound dressings, and then allicin is added to PCL and silk fibroin to expand antibacterial properties. The polymer solutions are subjected to various electrospinning parameters, and allicin-containing and non-allicin fibres are prepared. Fibres are examined by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), contact angle analysis, mechanical testing, bacterial culture, and 3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT). The SEM results show that the addition of fibroin and allicin at a constant voltage provides a direct relationship between the distance and the diameter of the fibres. Also, the total variation algorithm is used for denoising the signal of FTIR that the results confirm the functional groups present in the fibres. Furthermore, the contact angle test for allicin-free fibres shows that the contact angle of these fibres is 133.3° that decreases to 85.5° by adding allicin to the structure. Moreover, the tensile test of allicin-free fibres shows that Young's modulus of these fibres is 2.06 MPa, while the value increases to 5.12 MPa with the addition of allicin to the structure and at the end of the bacterial culture test, a growth inhibition zone is seen after 17 and 24 h. According to the obtained results, these fibres have the potential to be used in burn applications.

中文翻译：

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含有大蒜素的聚己内酯-丝心蛋白纳米纤维支架的制备和表征。

聚己内酯（PCL）和丝素蛋白用于制作纳米纤维伤口敷料，然后在PCL和丝素蛋白中加入大蒜素以扩大抗菌性能。聚合物溶液经受各种静电纺丝参数，制备出含大蒜素和不含大蒜素的纤维。纤维通过扫描电子显微镜 (SEM)、傅里叶变换红外光谱 (FTIR)、接触角分析、机械测试、细菌培养和 3-(4 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide ( MTT)。SEM 结果表明，在恒定电压下添加丝心蛋白和大蒜素提供了距离和纤维直径之间的直接关系。还，总变异算法用于对 FTIR 的信号进行去噪，结果证实了纤维中存在的官能团。此外，无大蒜素纤维的接触角测试表明，这些纤维的接触角为 133.3°，通过将大蒜素添加到结构中而降低到 85.5°。此外，无大蒜素纤维的拉伸试验表明，这些纤维的杨氏模量为 2.06 MPa，而在结构中加入大蒜素后，杨氏模量增加到 5.12 MPa，并且在细菌培养试验结束时，出现了生长抑制区。在 17 和 24 小时后可见。根据获得的结果，这些纤维具有用于烧伤应用的潜力。5° 通过在结构中添加大蒜素。此外，无大蒜素纤维的拉伸试验表明，这些纤维的杨氏模量为 2.06 MPa，而在结构中加入大蒜素后，杨氏模量增加到 5.12 MPa，并且在细菌培养试验结束时，出现了生长抑制区。在 17 和 24 小时后可见。根据获得的结果，这些纤维具有用于烧伤应用的潜力。5° 通过在结构中添加大蒜素。此外，无大蒜素纤维的拉伸试验表明，这些纤维的杨氏模量为 2.06 MPa，而在结构中加入大蒜素后，杨氏模量增加到 5.12 MPa，并且在细菌培养试验结束时，出现了生长抑制区。在 17 和 24 小时后可见。根据获得的结果，这些纤维具有用于烧伤应用的潜力。