Bio-based plastics production offers an alternative to the environmental problems posed by a significant reliance on fossil fuels. While dicarboxylic acids were essential bioplastic monomers, producing them on a large scale proved problematic. Recently, metabolic engineering has opened up interesting possibilities for producing dicarboxylic acids sustainably and efficiently. In this chapter, studies on the development of several dicarboxylic acid bioplastic monomers were presented. Furthermore, for different dicarboxylic acids, a variety of metabolic engineering strategies were highlighted, including improving the utilization rate of substrates, strengthening the catalytic efficiency of key enzymes, blocking branching pathways to balance metabolic flux, and improving cell physiological performance to promote biosynthesis. Finally, the remaining obstacles and solutions for building advanced dicarboxylic acid microbial systems were discussed.

中文翻译：

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生物塑料单体的微生物合成研究进展。

生物基塑料生产为严重依赖化石燃料带来的环境问题提供了一种替代方案。虽然二羧酸是必不可少的生物塑料单体，但大规模生产它们被证明是有问题的。最近，代谢工程为可持续和高效地生产二羧酸开辟了有趣的可能性。本章介绍了几种二羧酸生物塑料单体的开发研究。此外，针对不同的二羧酸，突出了多种代谢工程策略，包括提高底物利用率，加强关键酶的催化效率，阻断分支途径以平衡代谢通量，以及改善细胞生理性能以促进生物合成。最后，