The World Health Organisation reports higher levels of bacterial resistance to cephalosporins and carbapenems of above 54%. The sufficient redox capabilities of Ficus thonningii phytochemicals for Ag+ reduction to Ag0 and ultimately aggregation to nucleation are exploited for the first time in attempting to enhance the antibacterial activity. Solution colour change to brown due to surface plasmon resonance phenomenon confirmed nanoparticle fabrication with a UV/Vis absorption peak at 426 nm. Fourier Transform Infrared spectra revealed functional groups (C=C at 1620-1680 cm-1 ; C=H at 1400-1600 cm-1 aromatics) for encapsulation, stabilisation, and reduction of the silver ion. The Dynamic Light Scattering technique verified F. thonningii encapsulated silver nanoparticles particle size of 57.84 nm with a negative zeta potential (-19.8 mV) as proof of stability. The surface, shape and topographical features were shown by Scanning Electron Microscopy as spherical orientations. An enhanced antimicrobial efficacy was displayed by the nanoparticles (inhibition zones of 26.1, 24.1 and 15.2 mm from 11.5, 10.6 and 6.5 mm) for Staphylococcus aureus, Streptococcus pyrogenes and Escherichia coli, respectively, compared to Flucloxacillin standard that was in the ranges of 21.5, 23.5 and 25.7 mm. The enhanced potency provides a basis for diversified approaches of generating novel drugs for treating bacterial infections.

中文翻译：

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通过用 Ficus thonningii 水提取物植物制造银纳米粒子来增强抗菌活性。

世界卫生组织报告说，对头孢菌素和碳青霉烯类的细菌耐药性高于 54%。首次利用 Ficus thonningii 植物化学物质足够的氧化还原能力，将 Ag+ 还原为 Ag0 并最终聚集成核，以尝试增强抗菌活性。由于表面等离子共振现象，溶液颜色变为棕色，证实了纳米粒子的制造，在 426 nm 处具有 UV/Vis 吸收峰。傅立叶变换红外光谱揭示了用于包封、稳定和还原银离子的官能团（C=C 在 1620-1680 cm-1 ；C=H 在 1400-1600 cm-1 芳烃）。动态光散射技术验证了 F. thonningii 封装的银纳米粒子粒径为 57.84 nm，具有负 zeta 电位 (-19. 8 mV）作为稳定性的证明。表面、形状和形貌特征通过扫描电子显微镜显示为球形取向。与在 21.5 范围内的氟氯西林标准相比，纳米颗粒（从 11.5、10.6 和 6.5 毫米到 26.1、24.1 和 15.2 毫米的抑制区）分别对金黄色葡萄球菌、致热链球菌和大肠杆菌显示出增强的抗菌功效, 23.5 和 25.7 毫米。增强的效力为产生治疗细菌感染的新药的多样化方法提供了基础。5 mm) 分别用于金黄色葡萄球菌、致热链球菌和大肠杆菌，而氟氯西林标准品的范围为 21.5、23.5 和 25.7 mm。增强的效力为产生治疗细菌感染的新药的多样化方法提供了基础。5 mm) 分别用于金黄色葡萄球菌、致热链球菌和大肠杆菌，而氟氯西林标准品的范围为 21.5、23.5 和 25.7 mm。增强的效力为产生治疗细菌感染的新药的多样化方法提供了基础。