Although multiple studies have shown the role genetics plays in personality disorders and in addictions, few have studied the genetic aspects of their comorbidity. Here, we carried out a cross-sectional study in a sample comprising 303 Caucasian polydrug-consuming patients. The presence of personality disorders was evaluated using the International Personality Disorder Examination, and genes related to dopamine, serotonin and monoamine oxidase (MAO) were genotyped. A significant relationship was observed between the bp 279 DRD5 variable number of tandem repeat (VNTR) polymorphism and paranoid personality disorder $\text{◂()▸}\left(\text{OR}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}2.186\left(1.074;4.449\right);p=0.006\right)$. The bp 182 $\text{◂()▸}\left(\text{OR}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}0.407\left(0.178;0.931\right);p=0.033\right)$ and bp 184 $\text{◂()▸}\left(\text{OR}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}0.391\left(0.188;0.813\right);p=0.012\right)$ alleles of the MAOB VNTR were also associated with antisocial personality disorder. Among patients with addictions, paranoid personality disorder should also be considered in addition to the importance of antisocial and borderline personality disorders. The higher frequency of the bp 279 DRD5 VNTR allele found in patients with paranoid personality disorder, as well as the associations between alleles of the MAOB VNTR and antisocial personality disorder, support the monoaminergic bases of these personality disorders, especially when dealing with patients with addictions.

中文翻译：

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DRD5 和 MAO-B VNTR 多态性与多种药物使用者偏执和反社会人格障碍的关系

尽管多项研究表明遗传学在人格障碍和成瘾中所起的作用，但很少有人研究其合并症的遗传方面。在这里，我们对包含 303 名使用多种药物的高加索人患者的样本进行了横断面研究。使用国际人格障碍检查评估人格障碍的存在，并对与多巴胺、血清素和单胺氧化酶 (MAO) 相关的基因进行基因分型。bp 279 DRD5可变串联重复序列 (VNTR) 多态性与偏执型人格障碍之间存在显着关系$\text{◂()▸}\left(\text{或者}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}2.186\left(1.074;4.449\right);p=0.006\right)$. 英国石油公司 182$\text{◂()▸}\left(\text{或者}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}0.407\left(0.178;0.931\right);p=0.033\right)$和英国石油公司 184$\text{◂()▸}\left(\text{或者}\text{◂=▸}\left(95\%\mathrm{CI}\right)=\text{◂⋅▸}0.391\left(0.188;0.813\right);p=0.012\right)$MAOB VNTR的等位基因也与反社会人格障碍有关。在成瘾患者中，除了反社会和边缘性人格障碍的重要性外，还应考虑偏执型人格障碍。在偏执型人格障碍患者中发现的 bp 279 DRD5 VNTR 等位基因频率较高，以及MAOB VNTR 等位基因与反社会人格障碍之间的关联，支持这些人格障碍的单胺能碱基，尤其是在处理成瘾患者时.