Objective. There can be extreme variability between individual responses to exercise training, and the identification of genetic variants associated with individual variabilities in exercise-related traits could guide individualized exercise programs. We aimed to screen the exercise-related gene sensitivity of patients with acute myocardial infarction after PCI by establishing the gene spectrum of aerobic exercise and cardiopulmonary function sensitivity, test the effect of individualized precision exercise therapy, and provide evidence for the establishment of a precision medicine program for clinical research. Methods. Aerobic exercise- and cardiopulmonary function-related genes and single-nucleotide polymorphisms (SNPs) were obtained by data mining utilizing a major publicly available biomedical repository, the NCBI PubMed database. Biological samples from all participants underwent DNA testing. We performed SNP detection using Samtools. A total of 122 patients who underwent PCI were enrolled in the study. We screened the first 24 cases with a high mutation frequency for aerobic exercise- and cardiopulmonary function-related genes and the last 24 cases with a low mutation frequency and separated them into two groups for the exercise intervention experiment. Results. In both the low mutation frequency group and the high mutation frequency group, after 8 weeks of exercise intervention, 6 MWT distance, 6 MWT%, VO₂/kg at peak, and VO₂/kg at AT were significantly improved, and the effect in the high mutation frequency group was significantly higher than that in the low mutation frequency group (6 MWT distance: 468 vs. 439, ; 6 MWT%: 85 vs. 77, , VO₂/kg at peak: 14.7 vs. 13.3, ; VO₂/kg at AT: 11.9 vs. 13.3, ). Conclusions. There is extreme variability between individual responses to exercise training. The identification of genetic variants associated with individual variabilities in exercise-related traits could guide individualized exercise programs. We found that the subjects with a high mutation frequency in aerobic exercise and cardiopulmonary function-related genes achieved more cardiorespiratory fitness benefits in the aerobic exercise rehabilitation program and provided evidence for the establishment of a precision medicine program for clinical research.

中文翻译：

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经皮冠状动脉介入治疗后急性心肌梗死患者基于基因检测的心脏康复计划的结果

客观。个体对运动训练的反应之间可能存在极大的差异，识别与运动相关特征的个体差异相关的遗传变异可以指导个性化的运动计划。旨在通过建立有氧运动和心肺功能敏感性基因谱，筛选PCI术后急性心肌梗死患者运动相关基因敏感性，检验个体化精准运动治疗的效果，为精准医疗的建立提供依据。临床研究计划。方法. 有氧运动和心肺功能相关基因和单核苷酸多态性 (SNP) 是通过利用主要的公开生物医学资料库 NCBI PubMed 数据库进行数据挖掘获得的。所有参与者的生物样本都进行了 DNA 测试。我们使用 Samtools 进行 SNP 检测。共有 122 名接受 PCI 的患者参加了该研究。我们筛选出有氧运动和心肺功能相关基因突变频率高的前24例和突变频率低的后24例，并将他们分成两组进行运动干预实验。结果。在低突变频率组和高突变频率组中，运动干预8周后，MWT距离为6，MWT%为6，VO峰值 2 /kg，AT 时 VO _{2 /} kg 明显改善，且高突变频率组的效果显着高于低突变频率组（6 MWT 距离：468 vs. 439，; 6 MWT%：85 对 77，, VO ₂ /kg 峰值: 14.7 vs. 13.3,; VO ₂ /kg at AT：11.9 vs. 13.3，）。 结论。个体对运动训练的反应存在极大差异。识别与运动相关特征的个体变异性相关的遗传变异可以指导个性化的运动计划。我们发现有氧运动和心肺功能相关基因突变频率高的受试者在有氧运动康复计划中获得了更多的心肺健康益处，为建立临床研究的精准医学计划提供了证据。