Tumor necrosis factor-alpha (TNF-α) plays an important role in coronary heart disease (CHD), a chronic inflammatory process. Meanwhile, this pro-inflammatory factor is also involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Patients with RA correspond to a higher risk of CHD. TNF-α antagonist, one of the main treatments for RA, may reduce the risk of CHD in patients with RA. This review summarizes the pathogenesis of TNF-α in CHD and discusses the relationship between TNF-α antagonist and CHD in patients with RA.

中文翻译：

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类风湿性关节炎中 TNF-α 对 CHD 的影响以及 TNF-α 拮抗剂与 CHD 关系的系统评价

肿瘤坏死因子-α (TNF- α ) 在冠心病 (CHD) 这一慢性炎症过程中发挥着重要作用。同时，这种促炎因子也参与类风湿性关节炎（RA）等自身免疫性疾病的发病机制。RA 患者患 CHD 的风险较高。TNF- α拮抗剂是RA的主要治疗方法之一，可以降低RA患者发生CHD的风险。本文总结了TNF- α在CHD中的发病机制，并讨论了RA患者中TNF- α拮抗剂与CHD的关系。