The reprogramming of lipid metabolism and signaling pathways is the central aspect of cancer biology. It is hypothesized that tumor cells can alter the lipid spectrum in order to fulfill their metabolic requirements. Furthermore, they can alter potential tumors and suppressive mechanisms in which lipids' involvement is essential. Recently, more attentions have been given on the alteration of lipid metabolism during prostate cancer development, and investigations have shown unique regulation of "de novo" lipid synthesis in cancer cells. Cancer cells often use newer pathways and enzymes to simplify the synthesis of fatty acids, and the newly synthesized lipids affect cellular processes, which impacts cancer cell proliferation and survival outcomes. Herein, we aimed to study the influence of lipid profile alterations on the development of prostate cancer. We found that the total amounts of lipids and phospholipids were increased within tissues from men with the malignant prostate tumor as compared with the benign prostate tissue. Significant changes were also observed in the composition of saturated and unsaturated fatty acids within the malignant tumor tissues. Intensification of lipid peroxidation has also been observed in malignant prostate tumors compared to benign prostate tumors. Collectively, these findings further highlights the fact that lipid and fatty acids play unique regulatory roles in the cellular development of prostate malignant transformation.

中文翻译：

---

脂质和脂肪酸代谢在前列腺癌发展中的作用

脂质代谢和信号通路的重编程是癌症生物学的核心方面。据推测，肿瘤细胞可以改变脂质谱以满足其代谢需求。此外，它们可以改变潜在的肿瘤和抑制机制，其中脂质参与是必不可少的。最近，人们对前列腺癌发展过程中脂质代谢的改变给予了更多的关注，研究表明癌细胞中“从头”脂质合成的独特调节。癌细胞通常使用更新的途径和酶来简化脂肪酸的合成，而新合成的脂质会影响细胞过程，从而影响癌细胞的增殖和存活结果。在此处，我们旨在研究血脂变化对前列腺癌发展的影响。我们发现，与良性前列腺组织相比，患有恶性前列腺肿瘤的男性组织内的脂质和磷脂总量增加。恶性肿瘤组织中饱和和不饱和脂肪酸的组成也有显着变化。与良性前列腺肿瘤相比，在恶性前列腺肿瘤中也观察到脂质过氧化的加剧。总的来说，这些发现进一步强调了脂质和脂肪酸在前列腺恶性转化的细胞发育中发挥独特的调节作用。我们发现，与良性前列腺组织相比，患有恶性前列腺肿瘤的男性组织内的脂质和磷脂总量增加。恶性肿瘤组织中饱和和不饱和脂肪酸的组成也有显着变化。与良性前列腺肿瘤相比，在恶性前列腺肿瘤中也观察到脂质过氧化的加剧。总的来说，这些发现进一步强调了脂质和脂肪酸在前列腺恶性转化的细胞发育中发挥独特的调节作用。我们发现，与良性前列腺组织相比，患有恶性前列腺肿瘤的男性组织内的脂质和磷脂总量增加。恶性肿瘤组织中饱和和不饱和脂肪酸的组成也有显着变化。与良性前列腺肿瘤相比，在恶性前列腺肿瘤中也观察到脂质过氧化的加剧。总的来说，这些发现进一步强调了脂质和脂肪酸在前列腺恶性转化的细胞发育中发挥独特的调节作用。与良性前列腺肿瘤相比，在恶性前列腺肿瘤中也观察到脂质过氧化的加剧。总的来说，这些发现进一步强调了脂质和脂肪酸在前列腺恶性转化的细胞发育中发挥独特的调节作用。与良性前列腺肿瘤相比，在恶性前列腺肿瘤中也观察到脂质过氧化的加剧。总的来说，这些发现进一步强调了脂质和脂肪酸在前列腺恶性转化的细胞发育中发挥独特的调节作用。