Deltamethrin (DTM) is a synthetic pyrethroid widely used in the cultivation and management of several crops due to its insecticidal action. Application to crops of pyrethroids such as DTM can result in the of water and fruit consumed by fruit bats having a high pyrethroid content which may be harmful. Therefore the objective of this study was to evaluate the effects of short-term oral exposure of the fruit-eating bats (Artibeus lituratus) to two concentrations of DTM (0.02 and 0.04 mg/kg of papaya) on histopathology of the intestine, liver and kidney. The intestine of the animals exposed to both concentrations showed inflammatory infiltrate, degeneration, necrosis and goblet cell hyperplasia as the most frequent pathologies. Besides, the acid mucins showed an increase in the frequency of non-viable cells. The liver showed hepatocyte vacuolizatio and nuclear enlargement, as well as inflammatory infiltrate and steatosis. The kidneys of the exposed animals showed and inflammatory infiltrate, benign nephrosclerosis, vacuolization and necrosis. Also, DTM reduced nitric oxide synthesis, decreased glomerular diameter and increased glycogen percentage in the proximal tubules. Our results suggest that acute exposure to DTM at low concentrations has the potential to induce pronounced histopathological changes in vital organs, such as intestine, liver and kidney of fruit-eating bats.

中文翻译：

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口服溴氰菊酯后食果蝙蝠的形态生理变化

溴氰菊酯 (DTM) 是一种合成拟除虫菊酯，由于具有杀虫作用，广泛用于多种作物的种植和管理。将拟除虫菊酯（例如 DTM）施用到农作物上会导致果蝠消耗拟除虫菊酯含量高的水和水果，这可能是有害的。因此，本研究的目的是评估食果蝙蝠（ Artibeus lituratus ）短期口服暴露于两种浓度的 DTM（0.02 和 0.04 mg/kg 木瓜）对肠道、肝脏和肠道组织病理学的影响。肾。暴露于两种浓度的动物的肠道显示最常见的病变为炎症浸润、变性、坏死和杯状细胞增生。此外，酸性粘蛋白显示非活细胞的频率增加。肝脏显示肝细胞空泡化和核增大，以及炎症浸润和脂肪变性。暴露动物的肾脏显示炎症浸润、良性肾硬化、空泡形成和坏死。此外，DTM 还减少了一氧化氮合成，减小肾小球直径并增加近端肾小管中的糖原百分比。我们的研究结果表明，急性暴露于低浓度的 DTM 可能会引起重要器官的显着组织病理学变化，例如食果蝙蝠的肠道、肝脏和肾脏。