Neuroinflammation is a condition that contribute significantly to the pathogenesis and progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel therapeutic approach for the treatment of these disorders. Dexamethasone is a steroidal based anti-inflammatory drug with the potential to treat neuroinflammation. However, in order to maintain the efficacy of the drug, dexamethasone needs to be coupled with an effective drug delivery vehicle to be able to be transported across Central Nervous System. PLGA nanoparticles has been used as drug delivery vehicles for transport of drugs into the central nervous system. The article describes the preparation and encapsulation of dexamethasone loaded PLGA nanoparticles by solvent evaporation method. Statistical Experimental Design approach was performed, wherein Response Surface Methodology was carried out to optimize the parameters associated with synthesis process. Further, kinetic modeling and drug release profile were also determined. The drug encapsulated nanoparticles were validated for its effectiveness in vitro. Toxicity studies revealed the nanodrug to be non-cytotoxic and Griess assay highlighted its ability to lower neuroinflammation. Further, genetic studies revealed the anti-inflammatory properties of the nanodrug was successfully in modulating neuroinflammation.

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地塞米松包封 PLGA 纳米颗粒作为药物输送载体用于治疗神经炎症

神经炎症是一种对几种神经退行性疾病的发病机制和进展有显着影响的疾病。靶向神经炎症是治疗这些疾病的一种新的治疗方法。地塞米松是一种基于甾体的抗炎药，具有治疗神经炎症的潜力。然而，为了保持药物的疗效，地塞米松需要与有效的药物输送载体相结合，才能通过中枢神经系统运输。PLGA 纳米颗粒已被用作将药物转运到中枢神经系统的药物递送载体。文章介绍了溶剂蒸发法制备和包封负载地塞米松的 PLGA 纳米粒子。进行了统计实验设计方法，其中响应面方法进行了优化与合成过程相关的参数。此外，还确定了动力学模型和药物释放曲线。药物包封的纳米粒子的有效性得到验证体外。毒性研究表明纳米药物是非细胞毒性的，Griess 试验强调了它降低神经炎症的能力。此外，基因研究表明，纳米药物的抗炎特性成功地调节了神经炎症。