Background. Genetic variability of Helicobacter pylori is associated with various gastrointestinal diseases; however, little is known about interaction with sociodemographic in the development of premalignant lesions in Colombian patients. Methods. An analytical study was conducted including cases (patients with gastric atrophy, intestinal metaplasia, and gastric dysplasia) and controls (patients with nonatrophic gastritis). Sociodemographic information was obtained using a questionnaire. Histopathological diagnosis was performed according to the Sydney System. The cagA and vacA genotypes were established using polymerase chain reaction in paraffin blocks. The effect of each variable on the study outcome (premalignant lesion) is presented as odds ratio (OR) and 95% CI. A value of <0.05 was considered as statistically significant. Results. The vacA/s1m1 genotype increases the risk of developing premalignant lesions of the stomach (OR: 3.05, 95% IC: 1.57–5.91, ). Age and educational level showed a positive interaction with the s1m1 genotype (adjusted OR: 3.68, 95% CI: 1.73–7.82, ). The cagA genotype was not correlated to the development of premalignant lesions of the stomach (OR: 1.32, 95% CI: 0.90–1.94, ). Conclusions. The vacA genotype, age, and educational level are indicators of the risk of developing premalignant lesions of the stomach in the study population. Significance Statement. Genetic variability of H. pylori and sociodemographic information could be used to predict the risk of premalignant lesions in stomach in Colombian population.

中文翻译：

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幽门螺杆菌的毒力基因增加哥伦比亚人群癌前病变的风险

背景。幽门螺杆菌的遗传变异与多种胃肠道疾病有关；然而，对于哥伦比亚患者癌前病变发展过程中与社会人口学的相互作用知之甚少。方法。进行了一项分析研究，包括病例（胃萎缩、肠化生和胃发育不良的患者）和对照（非萎缩性胃炎患者）。社会人口学信息是通过问卷调查获得的。根据悉尼系统进行组织病理学诊断。cagA 和 vacA 基因型是在石蜡块中使用聚合酶链反应建立的。每个变量对研究结果（癌前病变）的影响表示为优势比 (OR) 和 95% CI。一个<0.05的值被认为具有统计学意义。结果。vacA/s1m1 基因型增加了发生胃癌前病变的风险（OR：3.05，95% IC：1.57–5.91，）。年龄和教育水平与 s1m1 基因型呈正相关（调整后的 OR：3.68，95% CI：1.73-7.82，）。cagA 基因型与胃癌前病变的发展无关（OR：1.32，95% CI：0.90-1.94，）。 结论。vacA 基因型、年龄和教育水平是研究人群发生胃癌前病变风险的指标。意义声明。幽门螺杆菌的遗传变异性和社会人口学信息可用于预测哥伦比亚人群胃部癌前病变的风险。