Endothelial dysfunction may contribute to the increased morbidity and mortality associated with coronary heart disease (CHD). Flow-mediated dilatation (FMD) is the most popular noninvasive method for vascular endothelial function evaluation. This meta-analysis aimed to investigate the association between FMD and CHD. We searched the publications listed in the PubMed, Web of Science, Scopus, and Embase databases. Stata 14 software was used to analyze the data. Standardized mean difference (SMD) was used to calculate FMD levels, and the effect sizes were expressed with a 95% confidence interval (CI). I² statistics were used to evaluate statistical heterogeneity. In this meta-analysis, 9 studies enrolled a total number of 943 participants, including 534 (56.63%) patients with CHD and 409 controls (43.37%). We found that patients with CHD showed a significantly lower FMD than the controls (SMD −0.706%; 95% CI: −0.985, −0.427; ) with high heterogeneity. In addition, funnel plot analysis suggested asymmetry that could be evidence of publication bias. But sensitivity analyses show that there were no influential studies. This meta-analysis provides evidence that patients with CHD show a significantly lower FMD than controls and highlights the literature on FMD as a hallmark in CHD diseases.

中文翻译：

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冠心病评估中的血流介导扩张：一项荟萃分析

内皮功能障碍可能导致与冠心病 (CHD) 相关的发病率和死亡率增加。血流介导的扩张 (FMD) 是最流行的无创血管内皮功能评估方法。这项荟萃分析旨在调查 FMD 与 CHD 之间的关联。我们检索了 PubMed、Web of Science、Scopus 和 Embase 数据库中列出的出版物。使用Stata 14软件对数据进行分析。标准化平均差 (SMD) 用于计算 FMD 水平，效应大小以 95% 置信区间 (CI) 表示。我²统计数据用于评估统计异质性。在这项荟萃分析中，9 项研究共招募了 943 名参与者，其中包括 534 名（56.63%）CHD 患者和 409 名对照者（43.37%）。我们发现 CHD 患者的 FMD 显着低于对照组（SMD -0.706%；95% CI：-0.985，-0.427；)具有高异质性。此外，漏斗图分析表明不对称可能是发表偏倚的证据。但敏感性分析表明，没有有影响力的研究。这项荟萃分析提供的证据表明，CHD 患者的 FMD 显着低于对照组，并强调了有关 FMD 的文献是 CHD 疾病的标志。