ABSTRACT

Working memory (WM) and long-term memory (LTM) tests have both overlapping and distinct neurocognitive processes. Hippocampal activity in fMRI studies–a hallmark of LTM–also occurs on WM tasks, typically during encoding or retrieval and sometimes (albeit rarely) through ‘late-delay’ periods. The Synaptic Theory of WM suggests that ‘activity-silent’ synaptic weights retain temporary, WM-relevant codes without sustained, elevated activity. The hippocampus temporarily retains item-context bindings during WM-delays that are typically ‘silent’ to fMRI, probably via oscillatory patterns of informational connectivity among task-relevant regions of cortex. Advancing WM theory will require modeling this dynamic interplay, as in the ‘Dynamic Processing Model of WM.

摘要

工作记忆（WM）和长期记忆（LTM）测试具有重叠和不同的神经认知过程。fMRI 研究中的海马活动（LTM 的标志）也发生在 WM 任务中，通常在编码或检索期间，有时（尽管很少）在“晚期延迟”期间。WM 的突触理论表明，“活动沉默”突触权重保留临时的、与 WM 相关的代码，但没有持续的、升高的活动。海马体在 WM 延迟期间暂时保留项目-上下文绑定，这通常对 fMRI 来说是“沉默的”，可能是通过任务相关皮层区域之间信息连接的振荡模式。推进 WM 理论需要对这种动态相互作用进行建模，如“WM 动态处理模型”。